Relative hazard of radioiodine as a function of (a) radiation quality and (b) age at exposure. Technical report, July 1976-February 1980

Technical Report · Tue Apr 01 04:00:00 EST 1980

OSTI ID:6839021

Book, S A

To identify the influence of the physical characteristics of radioiodine isotopes and thyroid gland maturity on the effectiveness of radioiodine exposure, two studies were performed: (1) The thyroidal effects of short-lived radioiodines were investigated, using rats to compare the effects of 132I and 131I. The authors found the same effect in goitrogen-stimulated rat thyroid glands (in terms of 50% suppression of thyroid gland weight increase) at doses of about 280 rads from 132I and 2500 rad from 131I, suggesting an approximately 9-fold increase in radiologic effectiveness of 132I over 131I; (2) The differences in age-related radiosensitivity of the guinea pig thyroid gland to radioiodine exposure were examined. Fetal, neonatal, weanling, and adult animals were exposed to single, graded doses of 131I, resulting in thyroid doses up to thousands of rads. Approximately 100 days after dosing, a single microCi of 131I was given and animals were killed 1 day later to provide data on thyroid weight and percent 131I uptake. Results of these data suggested the fetal and weanling thyroid glands were more radiosensitive than the adult thyroids while neonatal thyroids were less sensitive than adults. The extent of the increased radiosensitivity, however, was less than two fold.

• Research Organization: California Univ., Davis (USA). Lab. for Energy-Related Health Research
• OSTI ID: 6839021
• Report Number(s): NUREG/CR-1228
• Country of Publication: United States
• Language: English

Related Subjects

560162* -- Radionuclide Effects
Kinetics
& Toxicology-- Animals
Plants
Microorganisms
& Cells
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
AGE DEPENDENCE
ANIMALS
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
BODY
DAYS LIVING RADIOISOTOPES
ENDOCRINE GLANDS
GLANDS
GUINEA PIGS
HOURS LIVING RADIOISOTOPES
INTERMEDIATE MASS NUCLEI
IODINE 131
IODINE 132
IODINE ISOTOPES
ISOTOPES
LABORATORY ANIMALS
MAMMALS
NUCLEI
ODD-EVEN NUCLEI
ODD-ODD NUCLEI
ORGANS
RADIATION EFFECTS
RADIATION QUALITY
RADIOISOTOPES
RADIOSENSITIVITY
RATS
RODENTS
THYROID
VERTEBRATES