Radiation-induced thyroid tumors in infant rats

Journal Article · Wed Feb 01 04:00:00 EST 1978 · Radiat. Res.; (United States)

DOI:https://doi.org/10.2307/3574824· OSTI ID:7276873

Christov, K

Three hundred rad of x rays given to the neck region of 10-day-old rats led to the development of more thyroid tumors with a shorter latent period than the same dose of x rays given to the thyroid gland of adult animals. A subsequent treatment of irradiated animals with methylthiouracil significantly increased the number of thyroid adenomas and carcinomas and shortened the latent period. The thyroid tumors examined were predominantly of a follicular type. Papillary and medullary tumor variants were observed in a few animals only.

• Research Organization: Inst. of Oncology, Plovdivsko, Bulgaria
• OSTI ID: 7276873
• Journal Information: Radiat. Res.; (United States), Journal Name: Radiat. Res.; (United States) Vol. 73:2; ISSN RAREA
• Country of Publication: United States
• Language: English

Related Subjects

560152* -- Radiation Effects on Animals-- Animals
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ADENOMAS
AGE DEPENDENCE
ANIMALS
ANTITHYROID DRUGS
AZINES
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
BODY
BODY AREAS
CARCINOMAS
CHILDREN
DELAYED RADIATION EFFECTS
DISEASES
DRUGS
ELECTROMAGNETIC RADIATION
ENDOCRINE GLANDS
GLANDS
HETEROCYCLIC COMPOUNDS
HYDROXY COMPOUNDS
INFANTS
IONIZING RADIATIONS
IRRADIATION
LATENCY PERIOD
LOCAL IRRADIATION
MAMMALS
MAN
NECK
NEONATES
NEOPLASMS
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
ORGANIC SULFUR COMPOUNDS
ORGANS
PRIMATES
PYRIMIDINES
RADIATION EFFECTS
RADIATIONS
RADIOINDUCTION
RADIOSENSITIVITY
RADIOSENSITIVITY EFFECTS
RATS
RODENTS
THIOLS
THIOURACIL
THYROID
URACILS
VERTEBRATES
X RADIATION