DNA content in radiation-associated thyroid cancer

Journal Article · Thu Dec 01 04:00:00 EST 1988 · Surgery; (United States)

OSTI ID:6608707

Komorowski, R A; Deaconson, T F; Vetsch, R; Cerletty, J M; Wilson, S D

DNA content has been reported to be of prognostic significance in differentiated thyroid carcinoma. Since malignant tumors with irradiation as an initiator often contain DNA aberrations, the DNA content of well-differentiated thyroid carcinoma in patients with a prior history of low-dose head and neck irradiation was determined and compared with similar nonradiation-associated lesions. The DNA content of thyroid cancers from 53 patients was determined with use of flow cytometry. Sixteen radiation-associated thyroid carcinomas (11 papillary, 3 follicular, and 2 medullary) all were diploid. In a group of 37 nonradiation-associated tumors, 10 were aneuploid (10 of 29 papillary carcinomas and 0 of 2 follicular or 6 medullary carcinomas). This difference in DNA content is significant (p less than 0.02, Fisher's exact test). These findings were unexpected and suggest that if the initiating irradiation causes a DNA aberration, this aberration is not reflected in DNA content as measured by means of flow cytometry.

• Research Organization: Medical College of Wisconsin, Milwaukee (USA)
• OSTI ID: 6608707
• Journal Information: Surgery; (United States), Journal Name: Surgery; (United States) Vol. 104:6; ISSN SURGA
• Country of Publication: United States
• Language: English

Related Subjects

560151* -- Radiation Effects on Animals-- Man
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANEUPLOIDY
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
BODY
CARCINOMAS
CELL FLOW SYSTEMS
CHROMOSOMAL ABERRATIONS
DISEASES
DNA
ENDOCRINE GLANDS
GENETIC EFFECTS
GENETIC RADIATION EFFECTS
GLANDS
IRRADIATION
LOW DOSE IRRADIATION
MEDICINE
MUTATIONS
NEOPLASMS
NUCLEAR MEDICINE
NUCLEIC ACIDS
ORGANIC COMPOUNDS
ORGANS
PATIENTS
PLOIDY
RADIATION EFFECTS
RADIOINDUCTION
RADIOLOGY
RADIOTHERAPY
SIDE EFFECTS
SURGERY
THERAPY
THYROID
THYROIDECTOMY