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Comparative effects of iodine-132 and iodine-131 in rat thyroid glands

Journal Article · · Radiat. Res.; (United States)
DOI:https://doi.org/10.2307/3575400· OSTI ID:5243478
The thyroidal effects of short-lived radioiodines such as /sup 132/I, /sup 133/I, and /sup 135/I have not been well defined. We report here the results of a study comparing the effects of /sup 132/I and /sup 131/I. We found the same effect in goitrogen-stimulated rat thyroid glands (in terms of 50% suppression of thyroid gland weight increase) at injected activities of 93 ..mu..Ci /sup 132/I and 13 ..mu..Ci /sup 131/I. Doses, however, were 3 rad/..mu..Ci /sup 132/I and 194 rad/..mu..Ci /sup 131/I. The same 50% suppression for thyroid dose was found to occur at about 280 rad from /sup 132/I and 2500 rad from /sup 131/I, suggesting an approximately ninefold increase in radiologic effectiveness of /sup 132/I over /sup 131/I.
Research Organization:
Univ. of California, Davis
OSTI ID:
5243478
Journal Information:
Radiat. Res.; (United States), Journal Name: Radiat. Res.; (United States) Vol. 81:2; ISSN RAREA
Country of Publication:
United States
Language:
English