Age and its influence on effects of iodine-131 in guinea pig thyroid glands
Journal Article
·
· Radiat. Res.; (United States)
To identify the differences in age-related radiosensitivity of the thyroid gland to radioiodine exposure, we exposed fetal, neonatal, weanling, and adult guinea pigs to single graded doses of /sup 131/I. Injected quantities ranged from 1 to 100 ..mu..Ci /sup 131/I, depending on the age group, and resulted in thyroid doses ranging from hundreds to tens of thousands of rad. At approximately 100 days of age (or 100 days after dosing for adults), a single microcurie of /sup 131/I was given and animals were killed 1 day later to provide data on thyroid weight and percentage /sup 131/I uptake. Analysis of these data and information on pathology suggested that the fetal and weanling guinea pig thyroid glands were more radiosensitive than the adult thyroid; the neonatal thyroid appeared less radiosensitive than that of the adult. The increase in radiosensitivity of the young thyroid glands over the adults, however, did not appear to be greater than twofold. Nevertheless, the demonstration of age-related radiosensitivity requires that it be considered by those who assess radiologic risks to human populations.
- Research Organization:
- Univ. of California, Davis
- OSTI ID:
- 5175978
- Journal Information:
- Radiat. Res.; (United States), Journal Name: Radiat. Res.; (United States) Vol. 81:2; ISSN RAREA
- Country of Publication:
- United States
- Language:
- English
Similar Records
Thyroidal uptake and retention of $sup 131$I by pregnant and fetal guinea pigs
Relative hazard of radioiodine as a function of (a) radiation quality and (b) age at exposure. Technical report, July 1976-February 1980
EFFECT OF HYPOPHYSECTOMY OF THE PREGNANT RAT ON I$sup 131$ METABOLISM OF THE FETAL THYROID GLAND
Technical Report
·
Sun Jun 01 00:00:00 EDT 1975
·
OSTI ID:4059688
Relative hazard of radioiodine as a function of (a) radiation quality and (b) age at exposure. Technical report, July 1976-February 1980
Technical Report
·
Mon Mar 31 23:00:00 EST 1980
·
OSTI ID:6839021
EFFECT OF HYPOPHYSECTOMY OF THE PREGNANT RAT ON I$sup 131$ METABOLISM OF THE FETAL THYROID GLAND
Journal Article
·
Tue Oct 01 00:00:00 EDT 1963
· Endocrinology (U.S.)
·
OSTI ID:4634835
Related Subjects
560162* -- Radionuclide Effects
Kinetics
& Toxicology-- Animals
Plants
Microorganisms
& Cells
560172 -- Radiation Effects-- Nuclide Kinetics & Toxicology-- Animals-- (-1987)
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ADULTS
AGE DEPENDENCE
ANIMALS
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
BODY
DATA
DATA FORMS
DAYS LIVING RADIOISOTOPES
DOSE-RESPONSE RELATIONSHIPS
DOSES
ENDOCRINE GLANDS
EXPERIMENTAL DATA
FETUSES
GLANDS
GROWTH
GUINEA PIGS
INFORMATION
INJECTION
INTAKE
INTERMEDIATE MASS NUCLEI
INTERNAL IRRADIATION
IODINE 131
IODINE ISOTOPES
IRRADIATION
ISOLATED VALUES
ISOTOPES
MAMMALS
NEONATES
NUCLEI
NUMERICAL DATA
ODD-EVEN NUCLEI
ORGANS
PATHOLOGY
RADIATION DOSES
RADIATION EFFECTS
RADIOISOTOPES
RADIOSENSITIVITY
RADIOSENSITIVITY EFFECTS
RODENTS
THYROID
UPTAKE
VERTEBRATES
Kinetics
& Toxicology-- Animals
Plants
Microorganisms
& Cells
560172 -- Radiation Effects-- Nuclide Kinetics & Toxicology-- Animals-- (-1987)
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ADULTS
AGE DEPENDENCE
ANIMALS
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
BODY
DATA
DATA FORMS
DAYS LIVING RADIOISOTOPES
DOSE-RESPONSE RELATIONSHIPS
DOSES
ENDOCRINE GLANDS
EXPERIMENTAL DATA
FETUSES
GLANDS
GROWTH
GUINEA PIGS
INFORMATION
INJECTION
INTAKE
INTERMEDIATE MASS NUCLEI
INTERNAL IRRADIATION
IODINE 131
IODINE ISOTOPES
IRRADIATION
ISOLATED VALUES
ISOTOPES
MAMMALS
NEONATES
NUCLEI
NUMERICAL DATA
ODD-EVEN NUCLEI
ORGANS
PATHOLOGY
RADIATION DOSES
RADIATION EFFECTS
RADIOISOTOPES
RADIOSENSITIVITY
RADIOSENSITIVITY EFFECTS
RODENTS
THYROID
UPTAKE
VERTEBRATES