EFFECT OF HYPOPHYSECTOMY OF THE PREGNANT RAT ON I$sup 131$ METABOLISM OF THE FETAL THYROID GLAND
Pregnant rats were hypophysectomized on the 12th to 13th days of pregnancy and killed 8 to 9 days later. Seventeen to 18 hr before they were killed, carrier-free I/sup 131/ was injected either into the mothers or directly into the fetuses in utero. Hypophysectomy of the mother failed to influence fetal thyroid weight and had no significant influence on I/sup 131/ uptake by the fetal thyroid gland; nor did hypophysectomy of the mother change the pattern of distribution of I/sup 131/ among iodinated amino acids liberated by thyroglobulin hydrolysis of the fetal thyroid glands. These findings support the view that the hypophysial-thyroid axis functions in the rat before birth and that the deficiency of thyrotropic hormone induced in the mother by hypophysectomy does not affect the I/sup 131/ metabolism of the fetal thyroid gland. I/sup 131/ metabolism in the thyroid glands of hypophysectomized pregnant and hypophysectomized nonpregnant rats was compared. In the pregnant rats, I/sup 131/ uptakes were higher, and labeling of thyroidal thyroxine was higher and that of monoiodotyrosine lower than in corresponding nonpregnant rats. (auth)
- Research Organization:
- Univ. of California, Berkeley
- Sponsoring Organization:
- USDOE
- NSA Number:
- NSA-17-038712
- OSTI ID:
- 4634835
- Journal Information:
- Endocrinology (U.S.), Journal Name: Endocrinology (U.S.) Vol. Vol: 73; ISSN ENDOA
- Country of Publication:
- Country unknown/Code not available
- Language:
- English
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