THE EFFECT OF EXOGENOUS CALCIUM AND 1-THYROXINE ON PARTURITION IN THE RADIOIODINE THYROIDECTOMIZED RAT (thesis)
The effects of hypothyroidism and hypopathyroidism and replacement therapy on reproduction have been studied in the rat. Hypothyroidism was produced by surBery or bp irradiation with I/sup 131/ or At/sup 211/. Replacement therapy was attempted with calcium gluconate, desiccated thyroid substance, thyroxine, triiodothyronine, and a mixture of 90% thyroxine and 10% triiodothyronine. Radioisotopes were administered in sufficient quantity to produce highly sig nificant depressions is metabolic rate and thyroidal uptakes of a tracer dose of I/sup 131/. Enough time was allowed to elapse to permit complete metabolism of residual thyroid hormone before any attempt was made to breed the animals. The number of pregnancies was drastically reduced in the hypothyroid animals. Thyroid supplement brought the number of conceptions to well within the normal limits. No difference in fertility was observed when TH, T/sub 4/ or T/sub 3/ were used as the thyroid replacement. Still births and prolonged gestation were common in surgically thyroparathyroidectoraized animals and in animals whose thyroids had been destroyed with I/sup 131/. The number of fetal deaths was reduced, and the length of gestation waB reduced to the normal 23 days by intragastric administration of veterinary calcium gluconate daily for at least 5 days before term in the I/sup 131/-irradiated, thyroxine-treated animals. Calcium gluconate (C.P.) was apparently ineffective when given by mouth. Serum calcium levels were depressed to less than 6 mg% during parturition in I/ sup 131/-thyroidectomized, thyroxine-supported animals (46% of the cases tested). It is concluded that the thyroid gland is essential for the maintenance of the reproductive system in order to permit normal conception and pregnancy. However, its exact role, if any, in parturition could not be determined. It must be assumed that destruction of, or damage to the parathyroid glands was a major contributor to the difficulties observed in parturition. (auth)
- Research Organization:
- California Univ., Berkeley, CA (US). Lawrence Radiation Lab.
- NSA Number:
- NSA-14-009269
- OSTI ID:
- 4176021
- Report Number(s):
- UCRL-9004
- Country of Publication:
- United States
- Language:
- English
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