Toxicology and carcinogenesis studies of nitrofurantoin (CAS No. 67-20-9) in F344/n rats and B6C3F1 mice (feed studies). Technical report
Two-year toxicology and carcinogenesis studies were conducted by administering diets containing 0, 600, or 1,300 ppm nitrofurantoin to groups of 50 female rats for 103 weeks. Groups of 50 male rats and 50 mice of each sex were fed diets containing 0, 1,300 or 2,500 ppm for 103 weeks. Under the conditions of these 2-year feed studies, there was some evidence of carcinogenic activity of nitrofurantoin for male F344/N rats as shown by increased incidences of uncommon kidney tubular cell neoplasms. Uncommon osteosarcomas of the bone and neoplasms of the subcutaneous tissue were observed in dosed male rats. Incidences of interstitial cell adenomas of the testis and neoplasms of the preputial gland were decreased in the 2,500-ppm group of male rats. There was no evidence of carcinogenic activity of nitrofurantoin for female F344/N rats fed diets containing 600 ppm or 1,300 ppm for 2 years. Female rats may have been able to tolerate higher doses. There was no evidence of carcinogenic activity of nitrofurantoin for male B6C3F(1) mice fed diets containing 1,300 ppm or 2,500 ppm for 2 years. There was clear evidence of carcinogenic activity of nitrofurantoin for female B6C3F(1) mice as shown by increased incidences of tubular adenomas, benign mixed tumors, and granulosa cell tumors of the ovary.
- Research Organization:
- National Toxicology Program, Research Triangle Park, NC (USA)
- OSTI ID:
- 6832436
- Report Number(s):
- PB-90-197930/XAB; NIH/PUB-89-2597
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
NITRO COMPOUNDS
TOXICITY
BIOASSAY
CARCINOGENESIS
DOSE-RESPONSE RELATIONSHIPS
METABOLIC ACTIVATION
PROGRESS REPORT
RATS
SEX DEPENDENCE
TABLES
ANIMALS
DOCUMENT TYPES
MAMMALS
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
PATHOGENESIS
RODENTS
VERTEBRATES
560300* - Chemicals Metabolism & Toxicology