Toxicology and carcinogenesis studies of two pentachlorophenol technical-grade mixtures (CAS No. 87-86-5) in B6C3F1 mice (feed studies). Technical report series

Technical Report · Wed Mar 01 04:00:00 EST 1989

OSTI ID:5400481

McConnell, E E

Two-year toxicology and carcinogenicity studies were conducted by administering diets containing 100 or 200 ppm technical-grade pentachlorophenol or 100, 200 or 600 ppm Dowicide EC-7 to groups of 50 male and 50 female mice. Two groups of 35 male and 35 female mice were fed control diets. Under the conditions of the studies, there was clear evidence of carcinogenic activity for male B6C3F1 mice fed diets containing technical-grade pentachlorophenol, as shown by increased incidences of adrenal medullary and hepatocellular neoplasms. There was some evidence of carcinogenic activity for female B6C3F1 mice exposed to technical-grade pentachlorophenol, as shown by increased incidences of hemangiosarcomas and hepatocellular neoplasms. There was clear evidence of carcinogenic activity for male B6C3F1 mice exposed to pentachlorophenol, EC-7, as shown by increased incidences of adrenal medullary and hepatocellular neoplasms. There was clear evidence of carcinogenic activity for female B6C3F1 mice exposed to pentachlorophenol, EC-7, as shown by increased incidences of adrenal medullary and hepatocellular neoplasms and hemangiosarcomas.

• Research Organization: National Toxicology Program, Research Triangle Park, NC (USA)
• OSTI ID: 5400481
• Report Number(s): PB-89-216535/XAB; NTP-TR--349
• Country of Publication: United States
• Language: English

Related Subjects

560300* -- Chemicals Metabolism & Toxicology
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMALS
AROMATICS
BIOASSAY
CARCINOGENESIS
CHLORINATED AROMATIC HYDROCARBONS
DOCUMENT TYPES
DOSE-RESPONSE RELATIONSHIPS
ENVIRONMENTAL EXPOSURE
HALOGENATED AROMATIC HYDROCARBONS
HYDROXY COMPOUNDS
LABORATORY ANIMALS
MAMMALS
MATERIALS
MICE
ORGANIC CHLORINE COMPOUNDS
ORGANIC COMPOUNDS
ORGANIC HALOGEN COMPOUNDS
PATHOGENESIS
PHENOLS
PRESERVATIVES
PROGRESS REPORT
PUBLIC HEALTH
RODENTS
TOXIC MATERIALS
TOXICITY
VERTEBRATES
WOOD