No evidence of carcinogenicity for L-ascorbic acid (vitamin C) in rodents

Journal Article · Sun Jan 01 00:00:00 EST 1984 · J. Toxicol. Environ. Health; (United States)

DOI:https://doi.org/10.1080/15287398409530609· OSTI ID:5946516

Douglas, J F; Huff, J

Carcinogenesis studies of L-ascorbic acid were conducted by offering diets containing 0, 25,000 or 50,000 ppm L-ascorbic acid to groups of 50 F344/N rats and 50 B6C3F/sub 1/ mice of each sex for 103 wk. Survival of dosed and control female rats and of dosed and control female mice were comparable. Survival of high-dose male rats was slightly greater than that of the controls, whereas survival of high-dose male mice was significantly greater than that of the controls. There were not observed differences in neoplasms between treated and control groups that were considered related to L-ascorbic acid. In female rats, several lesions usually seen in aged animals showed a dose-related decline. Under the conditions of these studies, L-ascorbic acid given at 2.5% or 5.0% in the diet for 103 wk was not toxic or carcinogenic for male and female F344/N rats or for male and female B6C3F/sub 1/ mice. 13 references, 2 table.

• Research Organization: National Inst. of Environmental Health Sciences, Research Triangle Park, NC
• OSTI ID: 5946516
• Journal Information: J. Toxicol. Environ. Health; (United States), Vol. 14:4
• Country of Publication: United States
• Language: English

Related Subjects

63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ASCORBIC ACID
CARCINOGENESIS
TOXICITY
NEOPLASMS
VARIATIONS
DOSE-RESPONSE RELATIONSHIPS
EXPERIMENTAL DATA
MICE
RATS
SURVIVAL CURVES
ANIMALS
DATA
DISEASES
INFORMATION
MAMMALS
NUMERICAL DATA
PATHOGENESIS
RODENTS
VERTEBRATES
VITAMINS
560305* - Chemicals Metabolism & Toxicology- Vertebrates- (-1987)