Copper and zinc levels in serum and urine of cadmium-exposed people with special reference to renal tubular damage

Journal Article · Wed Feb 01 04:00:00 EST 1984 · Environ. Res.; (United States)

DOI:https://doi.org/10.1016/0013-9351(84)90005-7· OSTI ID:6829836

Nogawa, K; Yamada, Y; Honda, R; Tsuritani, I; Kobayashi, E; Ishizaki, M

Urinary copper and zinc concentrations and their serum levels were determined in women environmentally exposed to cadmium, including itai-itai disease patients and suspected patients, for evaluating the effect of cadmium exposure on metabolism of such essential metals as copper and zinc in human beings. Copper concentrations in the urine of cadmium-exposed women, especially itai-itai patients and suspected patients, were much higher than those on nonexposed women. Zinc concentrations in the urine of cadmium-exposed women, however, were not different from those of nonexposed women. Zinc levels in the serum of the itai-itai patients were somewhat lower than those of the nonexposed women. On the other hand, serum copper was almost equal in the cadmium-exposed and the nonexposed women. The correlation coefficient between ..beta../sub 2/-microglobulin amounts and copper concentrations in the urine of all women examined was as high as 0.95. It is concluded that exposure to cadmium will cause an increase in the excretion of copper in urine, which is attributable to renal tubular damage due to the cadmium exposure, and that urinary zinc excretion is not increased by cadmium exposure, even in the patients who suffer from severe renal tubular damage.

• Research Organization: Kanazawa Medical Univ., Uchinada-machi, Japan
• OSTI ID: 6829836
• Journal Information: Environ. Res.; (United States), Journal Name: Environ. Res.; (United States) Vol. 33:1; ISSN ENVRA
• Country of Publication: United States
• Language: English

Related Subjects

560306* -- Chemicals Metabolism & Toxicology-- Man-- (-1987)
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
BIOLOGICAL EFFECTS
BIOLOGICAL MATERIALS
BIOLOGICAL WASTES
BLOOD SERUM
BODY
BODY FLUIDS
CADMIUM
COPPER
ELEMENTS
INJURIES
KIDNEYS
MATERIALS
METABOLISM
METALS
ORGANS
PATIENTS
TRANSITION ELEMENTS
URINE
WASTES
ZINC