Preliminary toxicological study of Silastic 386 foam elastomer: catalyst

Technical Report · Thu Jun 01 00:00:00 EDT 1978

OSTI ID:6829323

Smith, D M; Drake, G A; London, J E; Thomas, R G

The acute oral LD/sup 30//sub 50/ values in mice and rats for cured Silastic 386 (95 parts foam elastomer plus 5 parts catalyst) were greater than 5 g/kg. According to classical guidelines, the mixture would be considered slightly toxic or practically nontoxic in both species. Skin application studies in the rabbit demonstrated the mixture to be mildly irritating. Eye irritation studies, also in the rabbit, showed the cured Silastic 386 to be a mild but transitory irritant. The sensitization study in the guinea pig did not demonstrate the mixture to be a sensitizer.

• Research Organization: Los Alamos Scientific Lab., N.Mex. (USA)
• DOE Contract Number: W-7405-ENG-36
• OSTI ID: 6829323
• Report Number(s): GA-7366-MS
• Country of Publication: United States
• Language: English

Related Subjects

560305* -- Chemicals Metabolism & Toxicology-- Vertebrates-- (-1987)
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMALS
BIOASSAY
BODY
CATALYSTS
DISPERSIONS
ELASTOMERS
EYES
GUINEA PIGS
MAMMALS
MICE
MIXTURES
ORAL ADMINISTRATION
ORGANIC COMPOUNDS
ORGANIC POLYMERS
ORGANS
POLYMERS
RABBITS
RATS
RODENTS
RUBBERS
SENSE ORGANS
SENSITIVITY
SILASTIC
SILICONES
SILOXANES
SKIN
TOXICITY
VERTEBRATES