Preliminary toxicological study of Silastic 386 foam elastomer

Technical Report · Thu Jun 01 00:00:00 EDT 1978

DOI:https://doi.org/10.2172/6754161· OSTI ID:6754161

Smith, D M; London, J E; Drake, G A; Thomas, R G

The acute oral LD/sup 30//sub 50/ values for Silastic 386 foam elastomer for rats and mice were greater than 5 g/kg. According to classical guidelines, the compound would be considered slightly toxic or practically nontoxic in both species. Skin application studies in the rabbit with Silastic 386 foam elastomer demonstrated it to be mildly irritating when administered cutaneously. This compound was a very mild but transitory irritant in rabbit eye application studies. The sensitization study in the guinea pig did not show the compound to be deleterious in this regard.

• Research Organization: Los Alamos Scientific Lab., N.Mex. (USA)
• DOE Contract Number: W-7405-ENG-36
• OSTI ID: 6754161
• Report Number(s): LA-7365-MS
• Country of Publication: United States
• Language: English

Related Subjects

560305* -- Chemicals Metabolism & Toxicology-- Vertebrates-- (-1987)
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMALS
BIOASSAY
BODY
ELASTOMERS
EYES
GUINEA PIGS
MAMMALS
MICE
ORAL ADMINISTRATION
ORGANIC COMPOUNDS
ORGANIC POLYMERS
ORGANS
POLYMERS
RABBITS
RATS
RODENTS
RUBBERS
SENSE ORGANS
SENSITIVITY
SILASTIC
SILICONES
SILOXANES
SKIN
TOXICITY
VERTEBRATES