Preliminary toxicological study of a component of a hydrogen getter 1,4-diphenylbutadyine (DPB)

Technical Report · Wed Jul 01 04:00:00 EDT 1981

OSTI ID:6194695

Drake, G A; London, J E; Ott, D G; Smith, D M

The acute oral LD/sub 30//sup 50/ values for 1,4-diphenylbutadyine (DPB) in rats and mice were greater than 5 g/kg, except when it was dissolved in corn oil (by sonification); then the LD/sub 30//sup 50/ was < 1.0 g/kg. According to classical guidelines, the material, when suspended in saline-Triton-X, would be considered slightly toxic or practically nontoxic in both species. Skin application studies in the rabbit with DPB demonstrated it to be mildly irritating when administered cutaneously. This material was a very mild but transitory irritant in rabbit eye application studies. The sensitization study in the guinea pig did not show the material to be deleterious.

• Research Organization: Los Alamos National Lab., NM (USA)
• DOE Contract Number: W-7405-ENG-36
• OSTI ID: 6194695
• Report Number(s): LA-8913-MS; ON: DE81028595
• Country of Publication: United States
• Language: English

Related Subjects

560305* -- Chemicals Metabolism &amp; Toxicology-- Vertebrates-- (-1987)
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ALKYNES
ANIMALS
DATA
EXPERIMENTAL DATA
GETTERS
HYDROCARBONS
INFORMATION
MAMMALS
MICE
NUMERICAL DATA
ORGANIC COMPOUNDS
RABBITS
RATS
RODENTS
TOXICITY
VERTEBRATES