Preliminary toxicological study of Sylgard 184 curing agent

Technical Report · Thu Jun 01 00:00:00 EDT 1978

DOI:https://doi.org/10.2172/6754156· OSTI ID:6754156

Smith, D M; London, J E; Drake, G A; Thomas, R G

The acute oral LD/sub 50//sup 30/ values for mice and rats receiving Sylgard 184 curing agent were greater than 5 g/kg. According to classical guidelines, the compound would be considered slightly toxic or practically nontoxic in both species. Skin application studies in the rabbit demonstrated the compound to be mildly irritating. Eye irritation studies, also in the rabbit, showed that Sylgard 184 curing agent was a mild but transitory irritant. The sensitization study in guinea pigs did not show the resin to be deleterious.

• Research Organization: Los Alamos Scientific Lab., N.Mex. (USA)
• DOE Contract Number: W-7405-ENG-36
• OSTI ID: 6754156
• Report Number(s): LA-7368-MS
• Country of Publication: United States
• Language: English

Related Subjects

560305* -- Chemicals Metabolism & Toxicology-- Vertebrates-- (-1987)
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMALS
BIOASSAY
BODY
EYES
GUINEA PIGS
MAMMALS
MICE
ORAL ADMINISTRATION
ORGANIC COMPOUNDS
ORGANIC POLYMERS
ORGANS
PETROCHEMICALS
PETROLEUM PRODUCTS
POLYMERS
RABBITS
RATS
RESINS
RODENTS
SENSE ORGANS
SENSITIVITY
SKIN
TOXICITY
VERTEBRATES