Preliminary toxicological study of Sylgard 184 encapsulating resin: curing agent

Technical Report · Thu Jun 01 00:00:00 EDT 1978

DOI:https://doi.org/10.2172/6682875· OSTI ID:6682875

Smith, D M; Drake, G A; London, J E; Thomas, R G

The acute oral LD/sub 50//sup 30/ values for Sylgard 184 (100 parts encapsulating resin plus 10 parts curing agent) were greater than 5 g/kg in rats and mice. According to classical guidelines, the mixture would be considered slightly toxic or practically nontoxic in both species. Skin application studies in the rabbit demonstrated the mixture to be mildly irritating. Eye irritation tests, also in the rabbit, showed the Sylgard 184 mixture to be a mild but transitory irritant. The sensitization study in the guinea pig demonstrated the mixture to be a very mild sensitizer in two of six animals.

• Research Organization: Los Alamos Scientific Lab., NM (USA)
• DOE Contract Number: W-7405-ENG-36
• OSTI ID: 6682875
• Report Number(s): LA-7370-MS
• Country of Publication: United States
• Language: English

Related Subjects

560305* -- Chemicals Metabolism & Toxicology-- Vertebrates-- (-1987)
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMALS
BODY
EYES
GUINEA PIGS
MAMMALS
MICE
ORGANS
POLYMERS
RABBITS
RATS
RODENTS
SENSE ORGANS
SENSITIVITY
SILICONES
SILOXANES
SKIN
TOXICITY
VERTEBRATES