Preliminary toxicological study of Silastic 386 catalyst

Technical Report · Thu Jun 01 00:00:00 EDT 1978

DOI:https://doi.org/10.2172/6754160· OSTI ID:6754160

Smith, D M; Drake, G A; Holland, L M; Jackson, D E; London, J E; Prine, J R; Thomas, R G

The calculated acute oral LD/sub 50//sup 30/ values for Silastic 386 catalyst were 1225 mg/kg in mice and 4350 mg/kg in rats. According to classical guidelines, the compound would be slightly to moderately toxic in both species. Skin application studies in the rabbit demonstrated the compound to be mildly irritating. The eye irritation study disclosed the compound to be a severe irritant causing conjunctivitis, photophobia, corneal edema, corneal ulceration, anterior uveitis, and keratitis. The sensitization study in the guinea pig did not show Silastic 386 catalyst to be deleterious in this regard.

• Research Organization: Los Alamos Scientific Lab., N.Mex. (USA)
• DOE Contract Number: W-7405-ENG-36
• OSTI ID: 6754160
• Report Number(s): LA-7367-MS
• Country of Publication: United States
• Language: English

Related Subjects

560305* -- Chemicals Metabolism & Toxicology-- Vertebrates-- (-1987)
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMALS
BIOASSAY
BODY
CARBOXYLIC ACIDS
CATALYSTS
DISEASES
ELASTOMERS
EYES
GUINEA PIGS
MAMMALS
MICE
MONOCARBOXYLIC ACIDS
OCTANOIC ACID
ORAL ADMINISTRATION
ORGANIC ACIDS
ORGANIC COMPOUNDS
ORGANIC POLYMERS
ORGANS
PATHOLOGICAL CHANGES
POLYMERS
RABBITS
RATS
RODENTS
RUBBERS
SENSE ORGANS
SENSITIVITY
SILASTIC
SILICONES
SILOXANES
SKIN
TIN COMPOUNDS
TOXICITY
VERTEBRATES