Preliminary toxicological study of Silastic 386 catalyst

Technical Report · Thu Jun 01 00:00:00 EDT 1978

DOI:https://doi.org/10.2172/6754160· OSTI ID:6754160

Smith, D M; Drake, G A; Holland, L M; Jackson, D E; London, J E; Prine, J R; Thomas, R G

The calculated acute oral LD/sub 50//sup 30/ values for Silastic 386 catalyst were 1225 mg/kg in mice and 4350 mg/kg in rats. According to classical guidelines, the compound would be slightly to moderately toxic in both species. Skin application studies in the rabbit demonstrated the compound to be mildly irritating. The eye irritation study disclosed the compound to be a severe irritant causing conjunctivitis, photophobia, corneal edema, corneal ulceration, anterior uveitis, and keratitis. The sensitization study in the guinea pig did not show Silastic 386 catalyst to be deleterious in this regard.

• Research Organization: Los Alamos National Lab. (LANL), Los Alamos, NM (United States)
• DOE Contract Number: W-7405-ENG-36
• OSTI ID: 6754160
• Report Number(s): LA-7367-MS
• Country of Publication: United States
• Language: English

Related Subjects

63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
CATALYSTS
OCTANOIC ACID
TIN COMPOUNDS
EYES
PATHOLOGICAL CHANGES
TOXICITY
BIOASSAY
GUINEA PIGS
MICE
ORAL ADMINISTRATION
RABBITS
RATS
SENSITIVITY
SILASTIC
SKIN
ANIMALS
BODY
CARBOXYLIC ACIDS
DISEASES
ELASTOMERS
MAMMALS
MONOCARBOXYLIC ACIDS
ORGANIC ACIDS
ORGANIC COMPOUNDS
ORGANIC POLYMERS
ORGANS
POLYMERS
RODENTS
RUBBERS
SENSE ORGANS
SILICONES
SILOXANES
VERTEBRATES
560305* - Chemicals Metabolism & Toxicology- Vertebrates- (-1987)