Potential tissue-imaging agents: 23-(trimethyl (117mSn)stannyl)-24-nor-5 alpha-cholan-3 beta-ol

Journal Article · Sat Oct 01 00:00:00 EDT 1983 · J. Med. Chem.; (United States)

DOI:https://doi.org/10.1021/jm00364a034· OSTI ID:6826778

Knapp, Jr, F F; Callahan, A P; Ambrose, K R; Ferren, L A; Butler, T A; Coffey, J L

Tin-117m-labeled 23-(trimethylstannyl)-24-nor-5 alpha-cholan-3 beta-ol (2) has been prepared by reaction of trimethyl (117mSn)tin lithium with 3 beta-acetoxy-23-bromo-24-nor-5 alpha-cholane (1). Tin-117m (2) shows pronounced adrenal uptake (2.5% injected dose) in female rats 1 day after injection. Furthermore, the adrenal to liver (9.1:1) and adrenal to blood (33.7:1) ratios are high after this period. The absorbed radiation dose values from (117mSn)2 to human organs have also been estimated by using rat tissue distribution and excretion data. (117mSn)2 is the first reported tissue-specific organic radiopharmaceutical labeled with this nuclide and may have potential as an adrenal imaging agent.

• OSTI ID: 6826778
• Journal Information: J. Med. Chem.; (United States), Journal Name: J. Med. Chem.; (United States) Vol. 26:10; ISSN JMCMA
• Country of Publication: United States
• Language: English

Related Subjects

38 RADIATION CHEMISTRY, RADIOCHEMISTRY, AND NUCLEAR CHEMISTRY
400702* -- Radiochemistry & Nuclear Chemistry-- Properties of Radioactive Materials
550601 -- Medicine-- Unsealed Radionuclides in Diagnostics
62 RADIOLOGY AND NUCLEAR MEDICINE
ADRENAL GLANDS
ANIMALS
BIOLOGICAL MATERIALS
BLOOD
BODY
BODY FLUIDS
CHEMICAL PREPARATION
COUNTING TECHNIQUES
DAYS LIVING RADIOISOTOPES
DIGESTIVE SYSTEM
DISTRIBUTION
DRUGS
ENDOCRINE GLANDS
EVEN-ODD NUCLEI
GLANDS
INTERMEDIATE MASS NUCLEI
ISOMERIC NUCLEI
ISOMERIC TRANSITION ISOTOPES
ISOTOPES
LABELLED COMPOUNDS
LIVER
MAMMALS
MATERIALS
NUCLEI
ORGANS
RADIATION DOSE DISTRIBUTIONS
RADIOISOTOPE SCANNING
RADIOISOTOPES
RADIONUCLIDE KINETICS
RADIOPHARMACEUTICALS
RATS
RODENTS
STABLE ISOTOPES
SYNTHESIS
TIN 117
TIN COMPOUNDS
TIN ISOTOPES
TISSUE DISTRIBUTION
VERTEBRATES