Tellurium-123m-labeled 23-(isopropyl telluro)-24-nor-5. cap alpha. -cholan-3. beta. -ol: a new potential adrenal imaging agent
Tellurium-123m-labeled 23-(isopropyl telluro)-24-nor-5..cap alpha..-cholan-3..beta..-ol (24-telluracholestanol, or 23-ITC) has been prepared as a potential adrenal-imaging agent. The new agent was synthesized by the coupling of 3..beta..-acetoxy-23-bromo-24-nor-5..cap alpha..-cholan with Te-123m-labeled sodium isopropyl tellurol. Tissue distribution experiments in both male and female rats indicate a high adrenal concentration of radioactivity following administration of this agent. In female rats the adrenal glands accumulated 4.5% of the injected radioactivity only 1 day after administration of Te-123m-23-ITC. The adrenal-to-liver ratio was 42 after 1 day, and this increased to 100 after 3 days. Chromatographic analyses of lipid extracts from adrenal, ovary, liver, and lungs suggest that this agent is metabolized by these tissues. Examination of the rats' excretory products has indicated that approximately 50% of the administered radioactivity is excreted in the feces with 5 days after injection of Te-123m-23-ITC. Moreover, the adrenals and ovaries of rats have been clearly imaged with this agent, both with a rectilinear scanner and with an RC type of proportional-counter camera.
- Research Organization:
- Oak Ridge National Lab., TN
- OSTI ID:
- 5643403
- Journal Information:
- J. Nucl. Med.; (United States), Journal Name: J. Nucl. Med.; (United States) Vol. 23:3; ISSN JNMEA
- Country of Publication:
- United States
- Language:
- English
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62 RADIOLOGY AND NUCLEAR MEDICINE
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ADRENAL GLANDS
ANIMALS
BIOLOGICAL ACCUMULATION
BIOLOGICAL LOCALIZATION
BODY
CHEMICAL PREPARATION
CHEMISTRY
DATA
DATA FORMS
DAYS LIVING RADIOISOTOPES
DISTRIBUTION
DRUGS
ENDOCRINE GLANDS
EVEN-ODD NUCLEI
EXPERIMENTAL DATA
FEMALE GENITALS
GLANDS
GONADS
INFORMATION
INJECTION
INTAKE
INTERMEDIATE MASS NUCLEI
INTERNAL CONVERSION RADIOISOTOPES
INTRAVENOUS INJECTION
ISOLATED VALUES
ISOMERIC NUCLEI
ISOMERIC TRANSITION ISOTOPES
ISOTOPES
LABELLED COMPOUNDS
LABELLING
MAMMALS
NUCLEI
NUMERICAL DATA
ORGANIC COMPOUNDS
ORGANS
OVARIES
RADIOACTIVE MATERIALS
RADIOCHEMISTRY
RADIOISOTOPES
RADIONUCLIDE KINETICS
RADIOPHARMACEUTICALS
RATS
RODENTS
STABLE ISOTOPES
STEROIDS
SYNTHESIS
TELLURIUM 123
TELLURIUM ISOTOPES
TISSUE DISTRIBUTION
VERTEBRATES