Radiation dosimetry of two new tellurium-123m-labeled adrenal-imaging agents: concise communication. [Dose calculations based on rat biological data]
The absorbed radiation doses to humans from 23-(isopropyl(/sup 123m/Te)telluro)-24-nor-5..cap alpha..-cholan-3 ..beta..-ol (Te-123m-23-ITC) and 24-(isopropyl(/sup 123m/Te)telluro)-chol-5-en-3..beta..-ol (Te-123m-24-ITC) have been calculated, based on rat biological data, to assess the relative radiation risks to humans from these two new adrenal-imaging agents. The estimated radiation doses to several critical organs have been compared with dose estimates for a variety of other radiolabeled steroids that have been designed as adrenal-imaging agents. Dose estimates to selected organs from Te-123m-23-ITC are as follows (rad/mCi): adrenals 98; ovaries 8.0; liver 1.6. Similar estimated values for Te-123m-24-ITC are: adrenals 210; ovaries 13; liver 2.0. The radiation dose estimates for these two agents are comparable to the calculated radiation doses from 6..beta..-((methyl(/sup 75/Se)seleno)methyl)-19-nor-cholest-5(10)-en-3..beta..-ol (Scintidren) and 19-(/sup 131/I)iodocholest-5-en-3..beta..-ol (NP-59), two agents currently in clinical use for the diagnosis of adrenal disease.
- Research Organization:
- Oak Ridge National Lab., TN
- OSTI ID:
- 5246367
- Journal Information:
- J. Nucl. Med.; (United States), Journal Name: J. Nucl. Med.; (United States) Vol. 21:5; ISSN JNMEA
- Country of Publication:
- United States
- Language:
- English
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62 RADIOLOGY AND NUCLEAR MEDICINE
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ADRENAL GLANDS
BODY
COMPARATIVE EVALUATIONS
COUNTING TECHNIQUES
DAYS LIVING RADIOISOTOPES
DIAGNOSIS
DIAGNOSTIC TECHNIQUES
DIGESTIVE SYSTEM
DISEASES
DOSES
DOSIMETRY
DRUGS
ENDOCRINE DISEASES
ENDOCRINE GLANDS
EVEN-ODD NUCLEI
FEMALE GENITALS
GLANDS
GONADS
INTERMEDIATE MASS NUCLEI
INTERNAL CONVERSION RADIOISOTOPES
ISOMERIC NUCLEI
ISOMERIC TRANSITION ISOTOPES
ISOTOPES
LABELLED COMPOUNDS
LIVER
NUCLEI
ORGANIC COMPOUNDS
ORGANS
OVARIES
PATIENTS
RADIATION DOSES
RADIOACTIVE MATERIALS
RADIOISOTOPE SCANNING
RADIOISOTOPES
RADIOPHARMACEUTICALS
SCINTISCANNING
STABLE ISOTOPES
STEROIDS
TELLURIUM 123
TELLURIUM ISOTOPES