Effect of structural modifications on the adrenal uptake of steroids labeled in the side chain with tellurium-123m
A series of structurally modified steroids labeled in the side chain with Te-123m have been prepared and tested in rats to determine the critical structural features required for maximal adrenal uptake of this new class of potential adrenal-imaging agents. The Te-123m steroids investigated contained structural modifications of both the nucleus and side chain. Tissue distribution experiments and rectilinear scans indicated that 23-(isopropyl telluro)-24-nor-5..cap alpha..-cholan-3..beta..-ol (saturated nucleus), and 24-(isopropyl telluro)-chol-5-en-3..beta..-ol (nuclear double bond) showed pronounced adrenal uptake after 1 day, with adrenal-to-liver ratios of 41 and 27, respectively. These results indicate that a combination of structural features is required for significant adrenal uptake of steroids labeled in the side chain with Te-123m. The structural requirements include a trans ring structure, an equatorial C-3 hydroxyl group, and a 17..beta.. side chain of moderate length.
- Research Organization:
- Oak Ridge National Lab., TN
- OSTI ID:
- 5409772
- Journal Information:
- J. Nucl. Med.; (United States), Journal Name: J. Nucl. Med.; (United States) Vol. 21:3; ISSN JNMEA
- Country of Publication:
- United States
- Language:
- English
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62 RADIOLOGY AND NUCLEAR MEDICINE
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ADRENAL GLANDS
BIOLOGICAL ACCUMULATION
BODY
COUNTING TECHNIQUES
DATA
DATA FORMS
DAYS LIVING RADIOISOTOPES
DIAGNOSTIC TECHNIQUES
DRUGS
ENDOCRINE GLANDS
EVEN-ODD NUCLEI
EXPERIMENTAL DATA
GLANDS
INFORMATION
INTERMEDIATE MASS NUCLEI
INTERNAL CONVERSION RADIOISOTOPES
ISOLATED VALUES
ISOMERIC NUCLEI
ISOMERIC TRANSITION ISOTOPES
ISOTOPES
LABELLED COMPOUNDS
MODIFICATIONS
MOLECULAR STRUCTURE
NUCLEI
NUMERICAL DATA
ORGANIC COMPOUNDS
ORGANS
RADIOACTIVE MATERIALS
RADIOISOTOPE SCANNING
RADIOISOTOPES
RADIONUCLIDE KINETICS
RADIOPHARMACEUTICALS
SCINTISCANNING
STABLE ISOTOPES
STEROIDS
TELLURIUM 123
TELLURIUM ISOTOPES