Treatment of lupus nephritis with total lymphoid irradiation. Observations during a 12-79-month followup

Journal Article · Fri Jul 01 04:00:00 EDT 1988 · Arthritis Rheum.; (United States)

DOI:https://doi.org/10.1002/art.1780310705· OSTI ID:6825612

Strober, S; Farinas, M C; Field, E H; Solovera, J J; Kiberd, B A; Myers, B D; Hoppe, R T

Seventeen patients with intractable lupus nephritis and nephrotic syndrome were treated with total lymphoid irradiation. Statistically significant improvement in mean renal disease and serologic activity parameters occurred within 3 months and persisted for at least 3 years. Although there was a marked reduction of T helper cell numbers and function after total lymphoid irradiation, recovery of these parameters was not associated with a return of disease activity. Risks of sterility, severe infections, and hematologic malignancy appeared to be lower than with alkylating agents.

• Research Organization: Stanford Univ. School of Medicine, CA (USA)
• OSTI ID: 6825612
• Journal Information: Arthritis Rheum.; (United States), Journal Name: Arthritis Rheum.; (United States) Vol. 31:7; ISSN ARHEA
• Country of Publication: United States
• Language: English

Related Subjects

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560151 -- Radiation Effects on Animals-- Man
62 RADIOLOGY AND NUCLEAR MEDICINE
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMAL CELLS
BIOLOGICAL EFFECTS
BIOLOGICAL MATERIALS
BIOLOGICAL RADIATION EFFECTS
BLOOD
BLOOD CELLS
BODY FLUIDS
CONNECTIVE TISSUE CELLS
DISEASES
GLOBULINS
IMMUNOGLOBULINS
INJURIES
IRRADIATION
LEUKOCYTES
LYMPHATIC SYSTEM
LYMPHOCYTES
MATERIALS
MEDICINE
NUCLEAR MEDICINE
ORGANIC COMPOUNDS
PATIENTS
POST-IRRADIATION EXAMINATION
PROTEINS
RADIATION EFFECTS
RADIATION INJURIES
RADIOLOGY
RADIOTHERAPY
SIDE EFFECTS
SOMATIC CELLS
THERAPY
UROGENITAL SYSTEM DISEASES