Skip to main content
OSTI.GOVU.S. Department of Energy Office of Scientific and Technical Information
U.S. Department of Energy
Office of Scientific and Technical Information
 

Treatment of intractable lupus nephritis with total lymphoid irradiation

Journal Article · · Ann. Intern. Med.; (United States)
; ; ; ; ; ; ;
Ten patients with lupus nephritis and marked proteinuria (3.9 g or more/d) that did not respond adequately to treatment with prednisone alone or prednisone in combination with azathioprine were treated with total lymphoid irradiation in an uncontrolled feasibility study. Within 6 weeks after the start of total lymphoid irradiation, the serum albumin level rose in all patients in association with a reduction in the serum level of anti-DNA antibodies, an increase in the serum complement level, or both. Improvement in these variables persisted in eight patients followed for more than 1 year, with the stabilization or reduction of the serum creatinine level. Urinary leakage of albumin was substantially reduced in all patients. Side effects associated with radiotherapy included transient constitutional complaints in ten patients, transient blood element depressions in three, localized viral and bacterial infections in four, and ovarian failure in one. The results suggest that total lymphoid irradiation may provide an alternative to cytotoxic drugs in the treatment of lupus nephritis.
Research Organization:
Stanford Univ. School of Medicine, CA
OSTI ID:
5555697
Journal Information:
Ann. Intern. Med.; (United States), Journal Name: Ann. Intern. Med.; (United States) Vol. 102:4; ISSN AIMEA
Country of Publication:
United States
Language:
English

Similar Records

Appraisal of lupus nephritis by renal imaging with gallium-67
Journal Article · Thu Aug 01 00:00:00 EDT 1985 · Am. J. Med.; (United States) · OSTI ID:5020163
Effect of total lymphoid irradiation on IgE antibody responses in rheumatoid arthritis and systemic lupus erythematosus
Journal Article · Mon Nov 30 23:00:00 EST 1987 · J. Allergy Clin. Immunol.; (United States) · OSTI ID:5592748
Treatment of lupus nephritis with total lymphoid irradiation. Observations during a 12-79-month followup
Journal Article · Fri Jul 01 00:00:00 EDT 1988 · Arthritis Rheum.; (United States) · OSTI ID:6825612

Related Subjects

550603* -- Medicine-- External Radiation in Therapy-- (1980-)
560151 -- Radiation Effects on Animals-- Man
62 RADIOLOGY AND NUCLEAR MEDICINE
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
BACTERIAL DISEASES
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
DISEASES
IMMUNE REACTIONS
INFECTIOUS DISEASES
LUPUS
LYMPHATIC SYSTEM
MEDICINE
NEPHRITIS
NUCLEAR MEDICINE
PATIENTS
RADIATION EFFECTS
RADIOLOGY
RADIOTHERAPY
SIDE EFFECTS
SKIN DISEASES
THERAPY
TUBERCULOSIS
UROGENITAL SYSTEM DISEASES