Effect of total lymphoid irradiation on IgE antibody responses in rheumatoid arthritis and systemic lupus erythematosus

Journal Article · Tue Dec 01 04:00:00 EST 1987 · J. Allergy Clin. Immunol.; (United States)

DOI:https://doi.org/10.1016/S0091-6749(87)80268-3· OSTI ID:5592748

Terr, A I; Moss, R B; Strober, S

Thirteen patients with rheumatoid arthritis and four patients with systemic lupus erythematosus and nephritis were treated with total lymphoid irradiation because of severe disease refractory to other forms of treatment. Serum samples before and after irradiation were tested for changes in total serum IgE and for changes in specific IgE antibodies to ryegrass pollen, dust mite, cat dander, and Alternaria. There were no statistically significant changes in total or specific IgE from lymphoid irradiation in these patients. The therapy caused a significant decrease in circulating total lymphocyte and Leu-3 (helper/inducer) T-lymphocyte counts. Therefore, reduction in circulating levels of helper/inducer T cells does not appear to influence preexisting levels of IgE antibodies.

• Research Organization: Stanford Univ. Medical Center, CA
• OSTI ID: 5592748
• Journal Information: J. Allergy Clin. Immunol.; (United States), Journal Name: J. Allergy Clin. Immunol.; (United States) Vol. 80:6; ISSN JACIB
• Country of Publication: United States
• Language: English

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560151* -- Radiation Effects on Animals-- Man
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMAL CELLS
ANTIBODIES
BIOLOGICAL EFFECTS
BIOLOGICAL MATERIALS
BIOLOGICAL RADIATION EFFECTS
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LEUKOCYTES
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ORGANIC COMPOUNDS
PATIENTS
PHENOTYPE
PROTEINS
RADIATION EFFECTS
RHEUMATIC DISEASES
SKELETAL DISEASES
SOMATIC CELLS