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Total lymphoid irradiation in refractory systemic lupus erythematosus

Journal Article · · Ann. Intern. Med.; (United States)
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In two patients with systemic lupus erythematosus, conventional therapy was considered to have failed because of persistent disease activity and unacceptable side effects. Both were treated with total lymphoid irradiation without clinical benefit, despite adequate immunosuppression as documented by markedly reduced numbers of circulating T lymphocytes and T-lymphocyte-dependent proliferative responses in vitro. The first patient developed herpes zoster, gram-negative septicemia, neurologic symptoms, and deterioration of lupus nephritis. The second patient developed massive bronchopneumonia, necrotic cutaneous lesions, and progressive nephritis and died 2 weeks after completion of radiotherapy. These observations, although limited to two patients, indicate that total lymphoid irradiation in patients with severe systemic lupus erythematosus should be regarded as strictly experimental.

Research Organization:
Hadassah Univ. Hospital, Jerusalem, Israel
OSTI ID:
5269201
Journal Information:
Ann. Intern. Med.; (United States), Journal Name: Ann. Intern. Med.; (United States) Vol. 1; ISSN AIMEA
Country of Publication:
United States
Language:
English

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Related Subjects

550603 -- Medicine-- External Radiation in Therapy-- (1980-)
560151* -- Radiation Effects on Animals-- Man
62 RADIOLOGY AND NUCLEAR MEDICINE
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ADRENAL HORMONES
BACTERIAL DISEASES
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
CORTICOSTEROIDS
DEATH
DISEASES
GLUCOCORTICOIDS
HORMONES
HYDROXY COMPOUNDS
IMMUNOSUPPRESSION
INFECTIOUS DISEASES
KETONES
LUPUS
LYMPHATIC SYSTEM
MEDICINE
NUCLEAR MEDICINE
ORGANIC COMPOUNDS
PATIENTS
PREDNISONE
PREGNANES
RADIATION EFFECTS
RADIOLOGY
RADIOTHERAPY
SIDE EFFECTS
SKIN DISEASES
STEROID HORMONES
STEROIDS
THERAPY
TUBERCULOSIS