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Suppressor cell hyperactivity relative to allogeneic lymphocyte proliferation as a manifestation of defective T-T-cell interactions in systemic lupus erythematosus

Journal Article · · Bull. Exp. Biol. Med. (Engl. Transl.); (United States)
OSTI ID:6438650
; ; ; ;
The authors study the state of immunoregulatory process in patients with systemic lupus erythematosus at the T-T-cell interaction level and seek to test the possibility of the pharmacological modulation of this process. The proliferative activity of mononuclear lymphocytes, extracted from the blood of ten lupus patients, was assessed by measuring the incorporation of tritiated thymidine into cultures stimulated by phytohemagglutinin, concanavalin, and theophylline. The comparative effects of each of these agents on the immunoregulatory and proliferative activity of the lymphocytes are reported.
Research Organization:
N.I. Pirogov Second Moscow Medical Institute, USSR
OSTI ID:
6438650
Journal Information:
Bull. Exp. Biol. Med. (Engl. Transl.); (United States), Journal Name: Bull. Exp. Biol. Med. (Engl. Transl.); (United States) Vol. 102:8; ISSN BEXBA
Country of Publication:
United States
Language:
English

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Related Subjects

550301* -- Cytology-- Tracer Techniques
550901 -- Pathology-- Tracer Techniques
59 BASIC BIOLOGICAL SCIENCES
AGGLUTININS
ANIMAL CELLS
ANTIBODIES
AROMATICS
AZAARENES
AZINES
BACTERIAL DISEASES
BIOLOGICAL EFFECTS
BIOLOGICAL MATERIALS
BLOOD
BLOOD CELLS
BODY FLUIDS
CARBOHYDRATES
CARDIOVASCULAR AGENTS
CELL PROLIFERATION
COMPARATIVE EVALUATIONS
CONCANAVALIN
CONNECTIVE TISSUE CELLS
DISEASES
DRUGS
ERYTHEMA
HEMAGGLUTININS
HETEROCYCLIC COMPOUNDS
IMMUNE REACTIONS
IMMUNOSUPPRESSION
INFECTIOUS DISEASES
INHIBITION
LABELLED COMPOUNDS
LECTINS
LEUKOCYTES
LUPUS
LYMPHOCYTES
MATERIALS
MITOGENS
MUCOPROTEINS
NUCLEOSIDES
NUCLEOTIDES
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
ORGANIC OXYGEN COMPOUNDS
PATHOGENESIS
PATIENTS
PHYTOHEMAGGLUTININ
POLYSACCHARIDES
PROTEINS
PURINES
PYRIMIDINES
RADIOASSAY
RIBOSIDES
SACCHARIDES
SKIN DISEASES
SOMATIC CELLS
SYMPTOMS
THEOPHYLLINE
THYMIDINE
TRITIUM COMPOUNDS
TUBERCULOSIS
UPTAKE
VASODILATORS
XANTHINES