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Effect of B-activin on human T suppressor cells

Journal Article · · Bull. Exp. Biol. Med. (Engl. Transl.); (United States)
DOI:https://doi.org/10.1007/BF00835893· OSTI ID:5783389
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The authors studied the influence of B-activin on the effect of human concanavalin A (con A)-induced T suppressor cells and also on the process of induction of T suppressor cells by con A and stimulation of proliferative activity of lymphocytes by phytohemagglutinin (PHA). Con A-induced suppression and the effect of B-activin on it were studied in a system in which the test cell culture and the culture for induction of suppressors were prepared simultaneously. Peripheral blood was obtained from blood donors for the experiments and during the preparation of the experiments, /sup 3/H-thymidine was added. The results of investigation of the influence of B-activin on the effect of con A-induced suppressors and also on the process of their induction are given. It is concluded that B-activin blocks the effect of con A-induced human suppressor cells but does not affect their induction, and B-activin does not affect proliferative activity of lymphocytes induced by PHA.

Research Organization:
All-Union Science Center for Surgery, Erevan, USSR
OSTI ID:
5783389
Journal Information:
Bull. Exp. Biol. Med. (Engl. Transl.); (United States), Journal Name: Bull. Exp. Biol. Med. (Engl. Transl.); (United States) Vol. 101:5; ISSN BEXBA
Country of Publication:
United States
Language:
English

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Related Subjects

550201 -- Biochemistry-- Tracer Techniques
550301* -- Cytology-- Tracer Techniques
59 BASIC BIOLOGICAL SCIENCES
ACTIVATION ENERGY
AGGLUTININS
ANIMAL CELLS
ANIMALS
ANTI-INFECTIVE AGENTS
ANTIBIOTICS
ANTIBODIES
ANTIMITOTIC DRUGS
ANTINEOPLASTIC DRUGS
AZINES
BIOLOGICAL EFFECTS
BIOLOGICAL MATERIALS
BIOLOGY
BIOSYNTHESIS
BLOOD
BLOOD CELLS
BODY FLUIDS
BONE MARROW CELLS
CARBOHYDRATES
CELL CULTURES
CELL PROLIFERATION
CONCANAVALIN
CONNECTIVE TISSUE CELLS
CYTOLOGY
DRUGS
ENERGY
HEMAGGLUTININS
HETEROCYCLIC COMPOUNDS
IMMUNE REACTIONS
IMMUNOASSAY
IMMUNOLOGY
IMMUNOSUPPRESSIVE DRUGS
INHIBITION
ISOTOPE APPLICATIONS
LABELLED COMPOUNDS
LECTINS
LEUKOCYTES
LYMPHOCYTES
MAMMALS
MAN
MATERIALS
MITOGENS
MITOMYCIN
MUCOPROTEINS
NUCLEOSIDES
NUCLEOTIDES
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
PHYTOHEMAGGLUTININ
POLYSACCHARIDES
PRIMATES
PROTEINS
PYRIMIDINES
RADIOASSAY
RADIOIMMUNOASSAY
RADIOIMMUNOLOGY
RESPONSE MODIFYING FACTORS
RIBOSIDES
SACCHARIDES
SOMATIC CELLS
STIMULATION
SYNTHESIS
THYMIDINE
TRACER TECHNIQUES
TRITIUM COMPOUNDS
VERTEBRATES