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Suppression of leukocyte inhibitory factor (LIF) production and (/sup 3/H)thymidine incorporation by concanavalin A-activated mononuclear cells

Journal Article · · Cell. Immunol.; (United States)
;

The capacity of human mononuclear (MN) cells pretreated with concanavalin A (Con A) to suppress the activity of fresh phytohemagglutinin (PHA)-pulsed mononuclear cells was assessed. Con A-pretreated MN cells suppressed leukocyte inhibitory factor (LIF) activity in supernatants of PHA-pulsed cell cultures and (/sup 3/H)thymidine incorporation by these cells. Suppression was obtained in both allogeneic and autologous systems with mitomycin-treated, irradiated, or untreated Con A-induced cells. Lymphocytes from two patients that, following treatment with Con A, did not suppress mitogen-induced proliferative response of normal cells also did not suppress LIF production.

Research Organization:
Univ. of Witwatersrand, Johannesburg, South Africa
OSTI ID:
6138146
Journal Information:
Cell. Immunol.; (United States), Journal Name: Cell. Immunol.; (United States) Vol. 43:1; ISSN CLIMB
Country of Publication:
United States
Language:
English

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Related Subjects

560121* -- Radiation Effects on Cells-- External Source-- (-1987)
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
AGGLUTININS
ANTIBIOTICS
ANTIMITOTIC DRUGS
AZINES
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BIOLOGICAL EFFECTS
BIOLOGICAL MATERIALS
BIOLOGICAL RADIATION EFFECTS
BLOOD
BLOOD CELLS
BODY FLUIDS
CARBOHYDRATES
DATA
DATA FORMS
DRUGS
EXPERIMENTAL DATA
GLOBULINS
HEMAGGLUTININS
HETEROCYCLIC COMPOUNDS
HYDROGEN ISOTOPES
IMMUNOSUPPRESSION
INFORMATION
ISOLATED VALUES
ISOTOPES
LEUKOCYTES
LIGHT NUCLEI
MITOGENS
MITOMYCIN
MUCOPROTEINS
NUCLEI
NUCLEOSIDES
NUCLEOTIDES
NUMERICAL DATA
ODD-EVEN NUCLEI
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
PATIENTS
PHYTOHEMAGGLUTININ
POLYSACCHARIDES
PROTEINS
PYRIMIDINES
RADIATION EFFECTS
RADIOISOTOPES
RIBOSIDES
SACCHARIDES
THYMIDINE
TRITIUM
YEARS LIVING RADIOISOTOPES