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Effect of total lymphoid irradiation on levels of serum autoantibodies in systemic lupus erythematosus and in rheumatoid arthritis

Journal Article · · Arthritis Rheum.; (United States)
; ;
The effects of total lymphoid irradiation (TLI) on serum levels of autoantibodies, and of antibodies to diphtheria toxoid, tetanus toxoid, and pneumococcal polysaccharide in patients with lupus nephritis were compared with those previously observed in rheumatoid arthritis (RA) patients. Baseline levels of antibodies to diphtheria toxoid and tetanus toxoid decreased significantly after TLI in patients with lupus and RA, but antibody levels to pneumococcal polysaccharide remained unchanged. After TLI, the levels of antinuclear and anti-DNA antibodies were reduced significantly in lupus, but levels of rheumatoid factor, antinuclear, and antigranulocyte antibodies all tended to increase in RA.
Research Organization:
Stanford Univ. Medical Center, CA
OSTI ID:
5633420
Journal Information:
Arthritis Rheum.; (United States), Journal Name: Arthritis Rheum.; (United States) Vol. 1; ISSN ARHEA
Country of Publication:
United States
Language:
English

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Related Subjects

550603 -- Medicine-- External Radiation in Therapy-- (1980-)
560151* -- Radiation Effects on Animals-- Man
62 RADIOLOGY AND NUCLEAR MEDICINE
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANTIBODIES
BACTERIAL DISEASES
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
DISEASES
INFECTIOUS DISEASES
INHIBITION
LUPUS
LYMPHATIC SYSTEM
MEDICINE
NUCLEAR MEDICINE
PATIENTS
RADIATION EFFECTS
RADIOLOGY
RADIOTHERAPY
RHEUMATIC DISEASES
SKELETAL DISEASES
SKIN DISEASES
THERAPY
TUBERCULOSIS