Appraisal of lupus nephritis by renal imaging with gallium-67

Journal Article · Thu Aug 01 04:00:00 EDT 1985 · Am. J. Med.; (United States)

DOI:https://doi.org/10.1016/0002-9343(85)90007-5· OSTI ID:5020163

Bakir, A A; Lopez-Majano, V; Hryhorczuk, D O; Rhee, H L; Dunea, G

To assess the activity of lupus nephritis, 43 patients with systemic lupus erythematosus (SLE) were studied by gallium imaging. Delayed renal visualization 48 hours after the gallium injection, a positive result, was noted in 25 of 48 scans. Active renal disease was defined by the presence of hematuria, pyuria (10 or more red blood cells or white blood cells per high-power field), proteinuria (1 g or more per 24 hours), a rising serum creatinine level, or a recent biopsy specimen showing proliferative and/or necrotizing lesions involving more than 20 percent of glomeruli. Renal disease was active in 18 instances, inactive in 23, and undetermined in seven (a total of 48 scans). Sixteen of the 18 scans (89 percent) in patients with active renal disease showed positive findings, as compared with only four of 23 scans (17 percent) in patients with inactive renal disease (p less than 0.001). Patients with positive scanning results had a higher rate of hypertension (p = 0.02), nephrotic proteinuria (p = 0.01), and progressive renal failure (p = 0.02). Mild mesangial nephritis (World Health Organization classes I and II) was noted only in the patients with negative scanning results (p = 0.02) who, however, showed a higher incidence of severe extrarenal SLE (p = 0.04). It is concluded that gallium imaging is a useful tool in evaluating the activity of lupus nephritis.

• Research Organization: Cook County Hospital, Chicago, IL
• OSTI ID: 5020163
• Journal Information: Am. J. Med.; (United States), Journal Name: Am. J. Med.; (United States) Vol. 2; ISSN AJMEA
• Country of Publication: United States
• Language: English

Related Subjects

550601* -- Medicine-- Unsealed Radionuclides in Diagnostics
62 RADIOLOGY AND NUCLEAR MEDICINE
ANIMAL CELLS
AZOLES
BETA DECAY RADIOISOTOPES
BIOLOGICAL MATERIALS
BIOPSY
BLOOD
BLOOD CELLS
BODY
BODY FLUIDS
CELL PROLIFERATION
CONNECTIVE TISSUE CELLS
COUNTING TECHNIQUES
CREATININE
DAYS LIVING RADIOISOTOPES
DIAGNOSIS
DIAGNOSTIC TECHNIQUES
DISEASES
ELECTRON CAPTURE RADIOISOTOPES
ERYTHROCYTES
GALLIUM 67
GALLIUM ISOTOPES
HETEROCYCLIC COMPOUNDS
IMIDAZOLES
IMINES
INTERMEDIATE MASS NUCLEI
ISOTOPES
KIDNEYS
LEUKOCYTES
LYMPHOCYTES
MATERIALS
NECROSIS
NEPHRITIS
NUCLEI
ODD-EVEN NUCLEI
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
ORGANS
PATHOLOGICAL CHANGES
PATIENTS
PROTEINS
RADIOISOTOPE SCANNING
RADIOISOTOPES
SOMATIC CELLS
UROGENITAL SYSTEM DISEASES