Identification of the ischemic border zone in reperfused canine myocardium using iodinated fatty acid analogs

Conference · Wed May 01 00:00:00 EDT 1985 · J. Nucl. Med.; (United States)

OSTI ID:6795050

Miller, D D; Gill, J B; Barlai-Kovach, M; Medelman, M A; Elmaleh, D E; Boucher, C A; Strauss, H W

The relationship of myocardial blood flow (MBF) to fatty acid uptake (FAU) was examined one hour after release of coronary occlusion in 8 anesthetized open chest dogs, MBF was determined both during coronary occlusion (SR) and one hour after release (SC) with left atrial microspheres. At the time of the second MBF determination, 100-200..mu..Ci of an iodinated modified fatty acid (I123-MFA) were given intravenously. MBF was calculated from the left ventricular (LV) SR and SC(LV activity/gram)/(arterial reference sample). The LV I123-FAU was expressed in a similar manner. SR and SC perfusion values were used to classify LV MBF into 205 normal (N), 37 persistently ischemic (I) and 133 ischemic-reperfused (R) segments for comparison to LV I123-FAU, I123-FAU was MBF-dependent (r=0.73; p<0.001) and significantly greater per unit reperfusion MBF in I vs R and N segments (0.29 +- .2 vs 0.14 +- .1; p<0.05). I123-FAU was MBF-independent over a wide range of reperfusion MBF. A similar protocol using single-photon emission computer tomography (SPECT) of closed-chested dogs showed increased I123-FAU vs thallium-201 in the ischemic border zone in 5/6 dogs. The authors conclude that SPECT non-invasively identifies excess I123-MFA extraction in ischemic but metabolizing myocardium that may be salvaged by sustained reperfusion.

• Research Organization: Massachusetts General Hospital, Boston, MA
• OSTI ID: 6795050
• Report Number(s): CONF-850611-
• Journal Information: J. Nucl. Med.; (United States), Journal Name: J. Nucl. Med.; (United States) Vol. 26:5; ISSN JNMEA
• Country of Publication: United States
• Language: English

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59 BASIC BIOLOGICAL SCIENCES
62 RADIOLOGY AND NUCLEAR MEDICINE
ANIMALS
BIOMEDICAL RADIOGRAPHY
BLOOD FLOW
BODY
CARBOXYLIC ACIDS
CARDIOGRAPHY
CARDIOVASCULAR SYSTEM
CHEMICAL PREPARATION
COMPARATIVE EVALUATIONS
COMPUTERIZED TOMOGRAPHY
COUNTING TECHNIQUES
DIAGNOSTIC TECHNIQUES
DISTRIBUTION
DOGS
DRUGS
EMISSION COMPUTED TOMOGRAPHY
HEART
LABELLED COMPOUNDS
LABELLING
MAMMALS
MEDICINE
METABOLISM
MONOCARBOXYLIC ACIDS
MUSCLES
MYOCARDIUM
NUCLEAR MEDICINE
ORGANIC ACIDS
ORGANIC COMPOUNDS
ORGANS
RADIOCARDIOGRAPHY
RADIOISOTOPE SCANNING
RADIOLOGY
RADIOPHARMACEUTICALS
SCINTISCANNING
SINGLE PHOTON EMISSION COMPUTED TOMOGRAPHY
SYNTHESIS
TISSUE DISTRIBUTION
TOMOGRAPHY
UPTAKE
VERTEBRATES