Recovery of glucose metabolism in reperfused canine myocardium demonstrated by positron-CT (PCT)

Conference · Sun Jan 01 04:00:00 EST 1984 · J. Nucl. Med.; (United States)

OSTI ID:6438119

Schwaiger, M; Sochor, H; Parodi, O; Grover, M; Hansen, H W; Selin, C; Schelbert, H R

The authors previously examined with PCT in chronic dogs the long term metabolic recovery during reperfusion after a 3 hr ischemic insult. Increased regional glucose utilization at 24 hrs of R accurately identified reversible tissue injury documented by late improvement in segmental function by ultrasonic crystals. To define the early metabolic events after a 3 hr LAD balloon occlusion, regional blood flow and glucose utilization was studied in 8 dogs with PCT, N-13 ammonia (NA) and F-18 deoxyglucose (FDG) at 2 hrs and at 24 hrs after R. The dogs were then thoracotomized and MBF by microspheres, arterio-venous differences for glucose, lactate and O/sub 2/ across the reperfused segment (LAD vein) and the left ventricle (coronary sinus) measured. Immediately after reperfusion, MBF and FDG uptake were 27 +- 24% and 21 +- 48% lower in the reperfused territory (RT) than in control myocardium (C). At 24 hrs, MBF by microspheres was and 22 +- 25% lower and FDG uptake 175 +- 73% higher in RT than in C. In the RT, consumption of glucose (by Fick method) was 202 +- 107% higher, of lactate 96 +- 85% lower and of O/sub 2/ 42 +- 26% lower than in the entire LV. PCT measured FDG uptake correlated with glucose consumption (r=0.94) and confirmed that the segmentally increased FDG uptake at 24 hrs reflected increased glucose utilization that, as indicated by the reduced lactate consumption, was partly anaerobic. The authors conclude that initially after R, glucose metabolism is depressed but increases above C within 24 hrs, a time course that now can be determined noninvasively with PCT and is useful for predicting functional recovery.

• Research Organization: UCLA School of Medicine, Los Angeles, CA
• OSTI ID: 6438119
• Report Number(s): CONF-840619-
• Conference Information: Journal Name: J. Nucl. Med.; (United States) Journal Volume: 25:5
• Country of Publication: United States
• Language: English

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59 BASIC BIOLOGICAL SCIENCES
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANAEROBIC CONDITIONS
ANIMALS
ANTIMETABOLITES
BIOLOGICAL RECOVERY
BODY
CARDIOVASCULAR SYSTEM
COMPUTERIZED TOMOGRAPHY
DIAGNOSTIC TECHNIQUES
DISTRIBUTION
DOGS
DRUGS
DYNAMIC FUNCTION STUDIES
EMISSION COMPUTED TOMOGRAPHY
FLUORODEOXYGLUCOSE
HEART
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LABELLED COMPOUNDS
MAMMALS
METABOLISM
MUSCLES
MYOCARDIUM
ORGANS
POSITRON COMPUTED TOMOGRAPHY
RADIOPHARMACEUTICALS
RECOVERY
TISSUE DISTRIBUTION
TOMOGRAPHY
TRACER TECHNIQUES
UPTAKE
VERTEBRATES