Assessment of myocardial injury after reperfusion with T1-201, Tc-99m pyrophosphate (PPi) and F-18 deoxyglucose (FDG)

Conference · Sun Jan 01 04:00:00 EST 1984 · J. Nucl. Med.; (United States)

OSTI ID:6518240

Sochor, H; Schwaiger, M; Hansen, H W; Parodi, O; Selin, C; Huang, S C; Ellison, D; Grover, M; Schelbert, H R

The authors previously demonstrated that enhanced glucose utilization assessed by FDG and Positron-CT in reperfused myocardium predicts functional recovery. This study compared segmental uptake of FDG with T1-201 and PPi as conventional indicators of tissue viability in 5 dogs, submitted to a 3 hr LAD occlusion followed by 24 hrs of reperfusion (R). Myocardial blood flow (MBF) was then determined by microspheres and T1-201, PPi and FDG administered i.v. Regional tracer concentrations were determined by well counting of tissue samples and grouped according to MBF (% of control). Severe flow reductions were associated with PPi uptake increase, T1-201 decrease and depressed glucose utilization representing mainly irreversible injury. Moderately reduced MBF areas showed the highest PPi uptake with T1-201 similar to MBF, but preserved FDG uptake not different from control, indicating partially viable tissue. Areas with MBF >60% had significantly increased PPi despite normal T1-201 uptake and enhanced glucose utilization and thus, preserved viability. Thus, assessment of tissue injury by conventional tracers such as T1-201 and PPi is limited. By contrast, quantification of residual glucose metabolism by PCT appears more accurate for evaluating myocardial viability and predicting potential functional recovery.

• Research Organization: UCLA School of Medicine, Los Angeles, CA
• OSTI ID: 6518240
• Report Number(s): CONF-840619-
• Conference Information: Journal Name: J. Nucl. Med.; (United States) Journal Volume: 25:5
• Country of Publication: United States
• Language: English

Related Subjects

550601 -- Medicine-- Unsealed Radionuclides in Diagnostics
551001* -- Physiological Systems-- Tracer Techniques
59 BASIC BIOLOGICAL SCIENCES
62 RADIOLOGY AND NUCLEAR MEDICINE
ALDEHYDES
ANIMALS
ANTIMETABOLITES
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BETA-PLUS DECAY RADIOISOTOPES
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
BIOLOGICAL RECOVERY
BLOOD CIRCULATION
BLOOD FLOW
BODY
CARBOHYDRATES
CARDIOVASCULAR SYSTEM
DISTRIBUTION
DOGS
DRUGS
DYNAMIC FUNCTION STUDIES
EVALUATION
FLUORINE 18
FLUORINE ISOTOPES
FLUORODEOXYGLUCOSE
GLUCOSE
HEART
HEXOSES
HOURS LIVING RADIOISOTOPES
INJURIES
INTERMEDIATE MASS NUCLEI
ISOMERIC TRANSITION ISOTOPES
ISOTOPE APPLICATIONS
ISOTOPES
LABELLED COMPOUNDS
LIGHT NUCLEI
MAMMALS
METABOLISM
MONOSACCHARIDES
MUSCLES
MYOCARDIUM
NUCLEI
ODD-EVEN NUCLEI
ODD-ODD NUCLEI
ORGANIC COMPOUNDS
ORGANS
OXYGEN COMPOUNDS
PATHOLOGICAL CHANGES
PHOSPHORUS COMPOUNDS
PYROPHOSPHATES
RADIATION EFFECTS
RADIATION INJURIES
RADIOISOTOPES
RADIONUCLIDE KINETICS
RADIOPHARMACEUTICALS
RECOVERY
SACCHARIDES
TECHNETIUM 99
TECHNETIUM ISOTOPES
TISSUE DISTRIBUTION
TRACER TECHNIQUES
UPTAKE
VERTEBRATES
YEARS LIVING RADIOISOTOPES