Assessment of myocardial injury after reperfusion with T1-201, Tc-99m pyrophosphate (PPi) and F-18 deoxyglucose (FDG)
The authors previously demonstrated that enhanced glucose utilization assessed by FDG and Positron-CT in reperfused myocardium predicts functional recovery. This study compared segmental uptake of FDG with T1-201 and PPi as conventional indicators of tissue viability in 5 dogs, submitted to a 3 hr LAD occlusion followed by 24 hrs of reperfusion (R). Myocardial blood flow (MBF) was then determined by microspheres and T1-201, PPi and FDG administered i.v. Regional tracer concentrations were determined by well counting of tissue samples and grouped according to MBF (% of control). Severe flow reductions were associated with PPi uptake increase, T1-201 decrease and depressed glucose utilization representing mainly irreversible injury. Moderately reduced MBF areas showed the highest PPi uptake with T1-201 similar to MBF, but preserved FDG uptake not different from control, indicating partially viable tissue. Areas with MBF >60% had significantly increased PPi despite normal T1-201 uptake and enhanced glucose utilization and thus, preserved viability. Thus, assessment of tissue injury by conventional tracers such as T1-201 and PPi is limited. By contrast, quantification of residual glucose metabolism by PCT appears more accurate for evaluating myocardial viability and predicting potential functional recovery.
- Research Organization:
- UCLA School of Medicine, Los Angeles, CA
- OSTI ID:
- 6518240
- Report Number(s):
- CONF-840619-
- Journal Information:
- J. Nucl. Med.; (United States), Vol. 25:5; Conference: 31. annual meeting of the Society of Nuclear Medicine, Los Angeles, CA, USA, 5 Jun 1984
- Country of Publication:
- United States
- Language:
- English
Similar Records
Recovery of glucose metabolism in reperfused canine myocardium demonstrated by positron-CT (PCT)
Accumulation of polymorphonuclear leukocytes in reperfused ischemic canine myocardium: relation with tissue viability assessed by fluorine-18-2-deoxyglucose uptake
Related Subjects
62 RADIOLOGY AND NUCLEAR MEDICINE
MYOCARDIUM
DYNAMIC FUNCTION STUDIES
PATHOLOGICAL CHANGES
RADIONUCLIDE KINETICS
RADIOPHARMACEUTICALS
TISSUE DISTRIBUTION
UPTAKE
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
BIOLOGICAL RECOVERY
BLOOD CIRCULATION
BLOOD FLOW
DOGS
EVALUATION
FLUORINE 18
FLUORODEOXYGLUCOSE
GLUCOSE
METABOLISM
PYROPHOSPHATES
RADIATION INJURIES
TECHNETIUM 99
TRACER TECHNIQUES
ALDEHYDES
ANIMALS
ANTIMETABOLITES
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BETA-PLUS DECAY RADIOISOTOPES
BODY
CARBOHYDRATES
CARDIOVASCULAR SYSTEM
DISTRIBUTION
DRUGS
FLUORINE ISOTOPES
HEART
HEXOSES
HOURS LIVING RADIOISOTOPES
INJURIES
INTERMEDIATE MASS NUCLEI
ISOMERIC TRANSITION ISOTOPES
ISOTOPE APPLICATIONS
ISOTOPES
LABELLED COMPOUNDS
LIGHT NUCLEI
MAMMALS
MONOSACCHARIDES
MUSCLES
NUCLEI
ODD-EVEN NUCLEI
ODD-ODD NUCLEI
ORGANIC COMPOUNDS
ORGANS
OXYGEN COMPOUNDS
PHOSPHORUS COMPOUNDS
RADIATION EFFECTS
RADIOISOTOPES
RECOVERY
SACCHARIDES
TECHNETIUM ISOTOPES
VERTEBRATES
YEARS LIVING RADIOISOTOPES
551001* - Physiological Systems- Tracer Techniques
550601 - Medicine- Unsealed Radionuclides in Diagnostics