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Title: Assessment of myocardial injury after reperfusion with T1-201, Tc-99m pyrophosphate (PPi) and F-18 deoxyglucose (FDG)

Abstract

The authors previously demonstrated that enhanced glucose utilization assessed by FDG and Positron-CT in reperfused myocardium predicts functional recovery. This study compared segmental uptake of FDG with T1-201 and PPi as conventional indicators of tissue viability in 5 dogs, submitted to a 3 hr LAD occlusion followed by 24 hrs of reperfusion (R). Myocardial blood flow (MBF) was then determined by microspheres and T1-201, PPi and FDG administered i.v. Regional tracer concentrations were determined by well counting of tissue samples and grouped according to MBF (% of control). Severe flow reductions were associated with PPi uptake increase, T1-201 decrease and depressed glucose utilization representing mainly irreversible injury. Moderately reduced MBF areas showed the highest PPi uptake with T1-201 similar to MBF, but preserved FDG uptake not different from control, indicating partially viable tissue. Areas with MBF >60% had significantly increased PPi despite normal T1-201 uptake and enhanced glucose utilization and thus, preserved viability. Thus, assessment of tissue injury by conventional tracers such as T1-201 and PPi is limited. By contrast, quantification of residual glucose metabolism by PCT appears more accurate for evaluating myocardial viability and predicting potential functional recovery.

Authors:
; ; ; ; ; ; ; ;
Publication Date:
Research Org.:
UCLA School of Medicine, Los Angeles, CA
OSTI Identifier:
6518240
Alternate Identifier(s):
OSTI ID: 6518240
Report Number(s):
CONF-840619-
Journal ID: CODEN: JNMEA
Resource Type:
Conference
Resource Relation:
Journal Name: J. Nucl. Med.; (United States); Journal Volume: 25:5; Conference: 31. annual meeting of the Society of Nuclear Medicine, Los Angeles, CA, USA, 5 Jun 1984
Country of Publication:
United States
Language:
English
Subject:
59 BASIC BIOLOGICAL SCIENCES; 62 RADIOLOGY AND NUCLEAR MEDICINE; MYOCARDIUM; DYNAMIC FUNCTION STUDIES; PATHOLOGICAL CHANGES; RADIONUCLIDE KINETICS; RADIOPHARMACEUTICALS; TISSUE DISTRIBUTION; UPTAKE; BIOLOGICAL EFFECTS; BIOLOGICAL RADIATION EFFECTS; BIOLOGICAL RECOVERY; BLOOD CIRCULATION; BLOOD FLOW; DOGS; EVALUATION; FLUORINE 18; FLUORODEOXYGLUCOSE; GLUCOSE; METABOLISM; PYROPHOSPHATES; RADIATION INJURIES; TECHNETIUM 99; TRACER TECHNIQUES; ALDEHYDES; ANIMALS; ANTIMETABOLITES; BETA DECAY RADIOISOTOPES; BETA-MINUS DECAY RADIOISOTOPES; BETA-PLUS DECAY RADIOISOTOPES; BODY; CARBOHYDRATES; CARDIOVASCULAR SYSTEM; DISTRIBUTION; DRUGS; FLUORINE ISOTOPES; HEART; HEXOSES; HOURS LIVING RADIOISOTOPES; INJURIES; INTERMEDIATE MASS NUCLEI; ISOMERIC TRANSITION ISOTOPES; ISOTOPE APPLICATIONS; ISOTOPES; LABELLED COMPOUNDS; LIGHT NUCLEI; MAMMALS; MONOSACCHARIDES; MUSCLES; NUCLEI; ODD-EVEN NUCLEI; ODD-ODD NUCLEI; ORGANIC COMPOUNDS; ORGANS; OXYGEN COMPOUNDS; PHOSPHORUS COMPOUNDS; RADIATION EFFECTS; RADIOISOTOPES; RECOVERY; SACCHARIDES; TECHNETIUM ISOTOPES; VERTEBRATES; YEARS LIVING RADIOISOTOPES 551001* -- Physiological Systems-- Tracer Techniques; 550601 -- Medicine-- Unsealed Radionuclides in Diagnostics

Citation Formats

Sochor, H., Schwaiger, M., Hansen, H.W., Parodi, O., Selin, C., Huang, S.C., Ellison, D., Grover, M., and Schelbert, H.R. Assessment of myocardial injury after reperfusion with T1-201, Tc-99m pyrophosphate (PPi) and F-18 deoxyglucose (FDG). United States: N. p., 1984. Web.
Sochor, H., Schwaiger, M., Hansen, H.W., Parodi, O., Selin, C., Huang, S.C., Ellison, D., Grover, M., & Schelbert, H.R. Assessment of myocardial injury after reperfusion with T1-201, Tc-99m pyrophosphate (PPi) and F-18 deoxyglucose (FDG). United States.
Sochor, H., Schwaiger, M., Hansen, H.W., Parodi, O., Selin, C., Huang, S.C., Ellison, D., Grover, M., and Schelbert, H.R. Sun . "Assessment of myocardial injury after reperfusion with T1-201, Tc-99m pyrophosphate (PPi) and F-18 deoxyglucose (FDG)". United States. doi:.
@article{osti_6518240,
title = {Assessment of myocardial injury after reperfusion with T1-201, Tc-99m pyrophosphate (PPi) and F-18 deoxyglucose (FDG)},
author = {Sochor, H. and Schwaiger, M. and Hansen, H.W. and Parodi, O. and Selin, C. and Huang, S.C. and Ellison, D. and Grover, M. and Schelbert, H.R.},
abstractNote = {The authors previously demonstrated that enhanced glucose utilization assessed by FDG and Positron-CT in reperfused myocardium predicts functional recovery. This study compared segmental uptake of FDG with T1-201 and PPi as conventional indicators of tissue viability in 5 dogs, submitted to a 3 hr LAD occlusion followed by 24 hrs of reperfusion (R). Myocardial blood flow (MBF) was then determined by microspheres and T1-201, PPi and FDG administered i.v. Regional tracer concentrations were determined by well counting of tissue samples and grouped according to MBF (% of control). Severe flow reductions were associated with PPi uptake increase, T1-201 decrease and depressed glucose utilization representing mainly irreversible injury. Moderately reduced MBF areas showed the highest PPi uptake with T1-201 similar to MBF, but preserved FDG uptake not different from control, indicating partially viable tissue. Areas with MBF >60% had significantly increased PPi despite normal T1-201 uptake and enhanced glucose utilization and thus, preserved viability. Thus, assessment of tissue injury by conventional tracers such as T1-201 and PPi is limited. By contrast, quantification of residual glucose metabolism by PCT appears more accurate for evaluating myocardial viability and predicting potential functional recovery.},
doi = {},
journal = {J. Nucl. Med.; (United States)},
number = ,
volume = 25:5,
place = {United States},
year = {Sun Jan 01 00:00:00 EST 1984},
month = {Sun Jan 01 00:00:00 EST 1984}
}

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