Modified fatty acid analog imaging: Correlation of SPECT and clearance kinetics in ischemic-reperfused myocardium

Conference · Wed May 01 04:00:00 EDT 1985 · J. Nucl. Med.; (United States)

OSTI ID:5875266

Miller, D D; Gill, J B; Barlai-Kovach, M; Nedelman, M A; Boucher, C A; Elmaleh, D E; Strauss, H W

To detect metabolic activity in ischemic-reperfused canine myocardium under conditions of varied myocardial blood flow (MBF), 6 anesthetized close-chested dogs underwent sequential thallium-201 (T1-201; 1-2mCi) and I-123 15-(p-(iodophenyl))-3-methylpentadecanoic acid (I123-MFA; 1.5-5.0mCi) imaging. The left anterior descending coronary artery was occluded for 1 hour, followed by release for 2-3 hours. T1-201 was injected IV and SPECT images recorded. At the conclusion of T1-SPECT, I123-MFA was injected and both sequential images and a second set of SPECT images recorded. Qualitative interpretation of T1-201 and I123-MFA SPECT images revealed I123-MFA uptake in excess of T1-201 uptake in the ischemic border zone in 5/6 dogs. The other dog had no qualitative difference. Initial (0-30 min) and overall (0-120 min) I123-MFA washout rates (w/o; counts/min) and clearance T1/2 values (min) were calculated in 3 dogs from regions-of-interest (ROI) set in the normal posterior wall (N), and the border (B) and central (C) ischemic zones. Thus, I123-MFA demonstrates different kinetic behavior in normal, ischemic and partially infarcted myocardium. Slow I123-MFA clearance from B and C zones may be due to either active metabolism by omega oxidation pathways or passive tracer efflux or both.

• Research Organization: Massachusetts General Hospital, Boston, MA
• OSTI ID: 5875266
• Report Number(s): CONF-850611-
• Conference Information: Journal Name: J. Nucl. Med.; (United States) Journal Volume: 26:5
• Country of Publication: United States
• Language: English

Related Subjects

550501 -- Metabolism-- Tracer Techniques
550601* -- Medicine-- Unsealed Radionuclides in Diagnostics
59 BASIC BIOLOGICAL SCIENCES
62 RADIOLOGY AND NUCLEAR MEDICINE
ANIMALS
BETA DECAY RADIOISOTOPES
BIOLOGICAL PATHWAYS
BODY
CARBOXYLIC ACIDS
CARDIOVASCULAR SYSTEM
COMPUTERIZED TOMOGRAPHY
DIAGNOSTIC TECHNIQUES
DIAGNOSTIC USES
DISTRIBUTION
DOGS
ELECTRON CAPTURE RADIOISOTOPES
EMISSION COMPUTED TOMOGRAPHY
FUNCTIONS
HEART
HOURS LIVING RADIOISOTOPES
INTERMEDIATE MASS NUCLEI
IODINE 123
IODINE ISOTOPES
ISOTOPES
LABELLING
MAMMALS
METABOLISM
MONOCARBOXYLIC ACIDS
MUSCLES
MYOCARDIUM
NUCLEI
ODD-EVEN NUCLEI
ORGANIC ACIDS
ORGANIC COMPOUNDS
ORGANS
RADIOISOTOPES
RETENTION FUNCTIONS
SINGLE PHOTON EMISSION COMPUTED TOMOGRAPHY
TISSUE DISTRIBUTION
TOMOGRAPHY
USES
VERTEBRATES