A new Os-191->Ir-191m generator for radionuclide angiocardiography
Ultrashort-lived radionuclides offer several advantages in angiocardiography in comparison to Tc-99m. Of the isotopes proposed for this application, I-191m (T/sub 1/2/=5 s) has several advantages when compared to Au-195m (T/sub 1/2/=30.5 s) (longer generator shelf-life) and Ag-109m (T/sub 1/2/= 40 s) (higher photon yield). The Ir-191m generator currently in clinical use suffers, however, from low Ir-191m yield (10% ml) and relatively high breakthrough of the Os-191 parent (5 x 10/sup -3/%/ml). The authors have recently developed a new Ir-191m generator that offers higher yield (20-30%/ml) and lower breakthrough (5 x 10/sup -4/%/ml) using an eluent that is only slightly hypertonic and does not require buffering prior to injection. A biodistribution study in mice shows the Os-191 breakthrough products, which are responsible for 80% of the patient radiation dose, to be cleared from the body more quickly than those of the earlier generator. This combination of 2-3 times higher yield, ten times lower breakthrough, and more rapid excretion results in a 30-50 fold decrease in the patient absorbed dose per study when compared to the earlier design. An additional advantage is the absence of a ''scavenger'' column. More than 200 radionuclide angiograms have been recorded in dogs with no adverse reactions and preliminary studies in mice have revealed no toxic effects attributable to the eluate.
- Research Organization:
- The Children's Hospital and Harvard Medical School, Boston, MA
- OSTI ID:
- 6794831
- Report Number(s):
- CONF-850611-; TRN: 87-010700
- Journal Information:
- J. Nucl. Med.; (United States), Vol. 26:5; Conference: 32. annual meeting of the Society of Nuclear Medicine, Houston, TX, USA, 2 Jun 1985
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
IRIDIUM 191
RADIOISOTOPE GENERATORS
YIELDS
DESIGN
PERFORMANCE TESTING
BLOOD VESSELS
COMPARATIVE EVALUATIONS
EXCRETION
MICE
OSMIUM 191
RADIATION DOSES
RADIONUCLIDE ADMINISTRATION
RADIONUCLIDE KINETICS
RADIOPHARMACEUTICALS
TISSUE DISTRIBUTION
ANIMALS
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BODY
CARDIOVASCULAR SYSTEM
CLEARANCE
DAYS LIVING RADIOISOTOPES
DISTRIBUTION
DOSES
DRUGS
EVEN-ODD NUCLEI
HEAVY NUCLEI
HOURS LIVING RADIOISOTOPES
IRIDIUM ISOTOPES
ISOMERIC TRANSITION ISOTOPES
ISOTOPES
LABELLED COMPOUNDS
MAMMALS
MINUTES LIVING RADIOISOTOPES
NUCLEI
ODD-EVEN NUCLEI
ORGANS
OSMIUM ISOTOPES
RADIOISOTOPES
RODENTS
SECONDS LIVING RADIOISOTOPES
STABLE ISOTOPES
TESTING
VERTEBRATES
550601* - Medicine- Unsealed Radionuclides in Diagnostics