A new Os-191->Ir-191m generator for radionuclide angiocardiography

Conference · Wed May 01 04:00:00 EDT 1985 · J. Nucl. Med.; (United States)

OSTI ID:6794831

Packard, A B; O'Brien, G M; Treves, S T

Ultrashort-lived radionuclides offer several advantages in angiocardiography in comparison to Tc-99m. Of the isotopes proposed for this application, I-191m (T/sub 1/2/=5 s) has several advantages when compared to Au-195m (T/sub 1/2/=30.5 s) (longer generator shelf-life) and Ag-109m (T/sub 1/2/= 40 s) (higher photon yield). The Ir-191m generator currently in clinical use suffers, however, from low Ir-191m yield (10% ml) and relatively high breakthrough of the Os-191 parent (5 x 10/sup -3/%/ml). The authors have recently developed a new Ir-191m generator that offers higher yield (20-30%/ml) and lower breakthrough (5 x 10/sup -4/%/ml) using an eluent that is only slightly hypertonic and does not require buffering prior to injection. A biodistribution study in mice shows the Os-191 breakthrough products, which are responsible for 80% of the patient radiation dose, to be cleared from the body more quickly than those of the earlier generator. This combination of 2-3 times higher yield, ten times lower breakthrough, and more rapid excretion results in a 30-50 fold decrease in the patient absorbed dose per study when compared to the earlier design. An additional advantage is the absence of a ''scavenger'' column. More than 200 radionuclide angiograms have been recorded in dogs with no adverse reactions and preliminary studies in mice have revealed no toxic effects attributable to the eluate.

• Research Organization: The Children's Hospital and Harvard Medical School, Boston, MA
• OSTI ID: 6794831
• Report Number(s): CONF-850611-
• Conference Information: Journal Name: J. Nucl. Med.; (United States) Journal Volume: 26:5
• Country of Publication: United States
• Language: English

Related Subjects

550601* -- Medicine-- Unsealed Radionuclides in Diagnostics
62 RADIOLOGY AND NUCLEAR MEDICINE
ANIMALS
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BLOOD VESSELS
BODY
CARDIOVASCULAR SYSTEM
CLEARANCE
COMPARATIVE EVALUATIONS
DAYS LIVING RADIOISOTOPES
DESIGN
DISTRIBUTION
DOSES
DRUGS
EVEN-ODD NUCLEI
EXCRETION
HEAVY NUCLEI
HOURS LIVING RADIOISOTOPES
IRIDIUM 191
IRIDIUM ISOTOPES
ISOMERIC TRANSITION ISOTOPES
ISOTOPES
LABELLED COMPOUNDS
MAMMALS
MICE
MINUTES LIVING RADIOISOTOPES
NUCLEI
ODD-EVEN NUCLEI
ORGANS
OSMIUM 191
OSMIUM ISOTOPES
PERFORMANCE TESTING
RADIATION DOSES
RADIOISOTOPE GENERATORS
RADIOISOTOPES
RADIONUCLIDE ADMINISTRATION
RADIONUCLIDE KINETICS
RADIOPHARMACEUTICALS
RODENTS
SECONDS LIVING RADIOISOTOPES
STABLE ISOTOPES
TESTING
TISSUE DISTRIBUTION
VERTEBRATES
YIELDS