A new Os-191->Ir-191m generator for radionuclide angiocardiography
Ultrashort-lived radionuclides offer several advantages in angiocardiography in comparison to Tc-99m. Of the isotopes proposed for this application, Ir-191m (T/sub 1/2/=5 s) has several advantages when compared to Au-195m (T /sub 1/2/=30.5 s) (longer generator shelf-life) and Ag-109m (T/sub 1/2/=40 s) (higher photon yield). The Ir-191m generator currently in clinical use suffers, however, from low Ir-191m yield (10% ml) and relatively high breakthrough of the Os-191 parent (5x10/sup -3/%/ml). The authors recently developed a new Ir-191m generator that offers higher yield (20-30%/ml) and lower breakthrough (5x10/sup -4/%/ml) using an eluent that is only slightly hypertonic and does not require buffering prior to injection. A biodistribution study in mice shows the Os-191 breakthrough products, which are responsible for 80% of the patient radiation dose, to be cleared from the body more quickly than those of the earlier generator. This combination of 2-3 times higher yield, ten times lower breakthrough, and more rapid excretion results in a 30-50 fold decrease in the patient absorbed dose per study when compared to the earlier design. An additional advantage is the absence of a ''scavenger'' column. More than 200 radionuclide agiograms have been recorded in dogs with no adverse reactions and preliminary studies in mice have revealed no toxic effects attributable to the eluate.
- Research Organization:
- The Children's Hospital and Harvard Medical School, Boston, MA
- OSTI ID:
- 6704313
- Report Number(s):
- CONF-850611-; TRN: 87-015213
- Journal Information:
- J. Nucl. Med.; (United States), Vol. 26:5; Conference: 32. annual meeting of the Society of Nuclear Medicine, Houston, TX, USA, 2 Jun 1985
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
37 INORGANIC
ORGANIC
PHYSICAL AND ANALYTICAL CHEMISTRY
GOLD 195
TISSUE DISTRIBUTION
IRIDIUM 191
RADIOISOTOPE GENERATORS
OSMIUM 191
DESIGN
SILVER 109
TECHNETIUM 99
ABSORPTION
BIOMEDICAL RADIOGRAPHY
BUFFERS
CHEMICAL REACTION YIELD
COMPARATIVE EVALUATIONS
DISTRIBUTION
DOGS
DOSE-RESPONSE RELATIONSHIPS
MICE
PERFORMANCE
RADIOCARDIOGRAPHY
UPTAKE
ANIMALS
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
CARDIOGRAPHY
DAYS LIVING RADIOISOTOPES
DIAGNOSTIC TECHNIQUES
ELECTRON CAPTURE RADIOISOTOPES
EVEN-ODD NUCLEI
GOLD ISOTOPES
HEAVY NUCLEI
HOURS LIVING RADIOISOTOPES
INTERMEDIATE MASS NUCLEI
INTERNAL CONVERSION RADIOISOTOPES
IRIDIUM ISOTOPES
ISOMERIC TRANSITION ISOTOPES
ISOTOPES
MAMMALS
MEDICINE
MINUTES LIVING RADIOISOTOPES
NUCLEAR MEDICINE
NUCLEI
ODD-EVEN NUCLEI
OSMIUM ISOTOPES
RADIOISOTOPES
RADIOLOGY
RODENTS
SECONDS LIVING RADIOISOTOPES
SILVER ISOTOPES
STABLE ISOTOPES
TECHNETIUM ISOTOPES
VERTEBRATES
YEARS LIVING RADIOISOTOPES
YIELDS
550602* - Medicine- External Radiation in Diagnostics- (1980-)
400202 - Isotope Effects
Isotope Exchange
& Isotope Separation