Current status of the Os-191. -->. Ir-191m generator

Technical Report · Tue Jan 01 04:00:00 EST 1985

OSTI ID:5754763

Packard, A B; O'Brien, G M; Treves, S

The advantages of ultrashort-lived radionuclides for angiography have been well documented in recent years. Although several isotopes are potentially useful in this application (e.g., Au-195m, Ag-109m, Ir-191m), Ir-191m offers several advantages. Among these advantages are a parent isotope (Os-191) with a sufficiently long half-life (15.4 d) to allow production of a generator with a reasonable shelf-life, high photon yield (129 keV, 26%; 66 keV, 55%), and ease of production of the parent isotope (i.e., neutron irradiation of Os-190). Ir-191m has not, however, been widely used for radionuclide angiocardiography because of a less than optimal generator design and the assumption that the half-life of Ir-191m (4.96 s) was too short to permit visualization of the left ventricle in adult patients. Recently we have, however, been able to develop a generator with higher Ir-191m yield (25 to 30%/ml), lower Os-191 breakthrough (< 5 x 10/sup -4/%) that is easier to assemble. In addition, the eluate of this new generator (0.001M oxalic acid/0.9% saline) does not require buffering prior to injection. We have also demonstrated that adequate studies of the left ventricle can be obtained in adults when sufficient quantities of isotope are injected. 16 refs., 2 figs., 2 tabs.

• Research Organization: Children's Hospital Corp., Boston, MA (USA)
• DOE Contract Number: AC02-82ER60084
• OSTI ID: 5754763
• Report Number(s): DOE/ER/60084-T2; ON: DE85008306
• Country of Publication: United States
• Language: English

Related Subjects

550601* -- Medicine-- Unsealed Radionuclides in Diagnostics
62 RADIOLOGY AND NUCLEAR MEDICINE
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BODY
CARDIOVASCULAR SYSTEM
COUNTING TECHNIQUES
DAYS LIVING RADIOISOTOPES
EVEN-ODD NUCLEI
HEART
HEAVY NUCLEI
HOURS LIVING RADIOISOTOPES
IRIDIUM 191
IRIDIUM ISOTOPES
ISOMERIC NUCLEI
ISOMERIC TRANSITION ISOTOPES
ISOTOPES
MINUTES LIVING RADIOISOTOPES
NUCLEI
ODD-EVEN NUCLEI
ORGANS
OSMIUM 191
OSMIUM ISOTOPES
RADIOISOTOPE GENERATORS
RADIOISOTOPE SCANNING
RADIOISOTOPES
SECONDS LIVING RADIOISOTOPES
STABLE ISOTOPES
YIELDS