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New osmium-191. -->. iridium-191m generator

Journal Article · · J. Nucl. Med.; (United States)
OSTI ID:6667523
; ; ;

A new osmium-191..-->..iridium-191m generator suitable for first-pass radionuclide angiocardiography has been developed. This generator system allows repeated elutions of 4.96-sec iridium-191m from its 15.4-day Os-191 parent. The Os-191 is loaded on an anion-exchange column (AGMP-1) and Ir-191m eluted with 0.9% NaCl at pH 1. Each elution (0.6 to 1 ml) of the generator yields about 7 to 10% Ir-191m and gives 0.003 to 0.008% of Os-191 breakthrough. Toxicity studies of the generator eluate carried out in animals support the safety of using iridium-191m in humans. The long shelf-life of the generator (approx. = 2 wk) will allow medical centers to use Ir-191m for routine clinical diagnosis. Iridium-191m obtained by this method should find additional useful applications in nuclear medicine.

Research Organization:
Harvard Medical School, Boston, MA
OSTI ID:
6667523
Journal Information:
J. Nucl. Med.; (United States), Journal Name: J. Nucl. Med.; (United States) Vol. 21:12; ISSN JNMEA
Country of Publication:
United States
Language:
English

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Related Subjects

38 RADIATION CHEMISTRY, RADIOCHEMISTRY, AND NUCLEAR CHEMISTRY
400702 -- Radiochemistry & Nuclear Chemistry-- Properties of Radioactive Materials
550601* -- Medicine-- Unsealed Radionuclides in Diagnostics
551001 -- Physiological Systems-- Tracer Techniques
59 BASIC BIOLOGICAL SCIENCES
62 RADIOLOGY AND NUCLEAR MEDICINE
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BIOLOGICAL HALF-LIFE
CHEMICAL PREPARATION
COMPARATIVE EVALUATIONS
COUNTING TECHNIQUES
DAYS LIVING RADIOISOTOPES
DIAGNOSTIC TECHNIQUES
DIAGNOSTIC USES
DOSES
DRUGS
DYNAMIC FUNCTION STUDIES
EVEN-ODD NUCLEI
HEAVY NUCLEI
HOURS LIVING RADIOISOTOPES
IRIDIUM 191
IRIDIUM ISOTOPES
ISOMERIC NUCLEI
ISOMERIC TRANSITION ISOTOPES
ISOTOPES
LABELLED COMPOUNDS
MATERIALS
MINUTES LIVING RADIOISOTOPES
NUCLEI
ODD-EVEN NUCLEI
OSMIUM 191
OSMIUM ISOTOPES
PATIENTS
RADIATION DOSES
RADIOACTIVE MATERIALS
RADIOISOTOPE GENERATORS
RADIOISOTOPE SCANNING
RADIOISOTOPES
RADIONUCLIDE KINETICS
RADIOPHARMACEUTICALS
SCINTISCANNING
SECONDS LIVING RADIOISOTOPES
STABLE ISOTOPES
SYNTHESIS
TOXICITY
USES