A new osmium-191/iridium-191m generator system
Ir-191m (t/sub 1/2/ 4.96 sec) has very attractive properties for radionuclide angiography and is obtained from the long-lived (15 d) Os-191 parent. Because of the long parent half-life, generators could have an extended shelf-life (2-3 weeks) if the problems of low Ir-191m yields and rapidly increasing Os-191 breakthrough could be overcome. A new /sup 191/Os//sup 191m/Ir generator system has now been developed involving adsorption of K/sub 2/OsCl/sub 6/ (Os-IV) on heat-treated (800/sup 0/C) activated coconut carbon. This system gives consistently good Ir-191m yields of --35-40% for a 2 ml bolus and low Os-191 breakthrough of --1 x 10/sup -4/%/bolus over a 2-3 week period. In addition, this simple system does not require a scavenger column and no radiolysis has been detected after loading up to 1 Ci of Os-191. The generator is prepared from 140-230 mesh carbon and eluted with pH 2 - 0.9% NaCl containing 0.25% KI. The use of KI in the eluting solution is critical for generator performance. Yield and breakthrough do not change for up to 250 elutions of the prototype system. The generator eluent is neutralized to physiological pH and isotonicity with 0.13 M Tris buffer immediately prior to intravenous injection. No adverse effects have been observed in studies in normal adult volunteers. This new system has a long shelf-life and represents a simple, readily available source of Ir-191m for radionuclide angiography.
- Research Organization:
- Nuclear Medicine Group, Oak Ridge National Lab., Oak Ridge, TN
- OSTI ID:
- 6704281
- Report Number(s):
- CONF-850611-
- Journal Information:
- J. Nucl. Med.; (United States), Journal Name: J. Nucl. Med.; (United States) Vol. 26:5; ISSN JNMEA
- Country of Publication:
- United States
- Language:
- English
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New osmium-191. -->. iridium-191m generator
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62 RADIOLOGY AND NUCLEAR MEDICINE
ACTIVATED CARBON
ADSORBENTS
ALKALI METAL COMPOUNDS
ANIMALS
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
BIOMEDICAL RADIOGRAPHY
BUFFERS
CARBON
CHEMICAL PREPARATION
CHEMICAL REACTION YIELD
CHLORIDES
CHLORINE COMPOUNDS
COORDINATED RESEARCH PROGRAMS
DAYS LIVING RADIOISOTOPES
DESIGN
DIAGNOSTIC TECHNIQUES
DOSE-RESPONSE RELATIONSHIPS
ELEMENTS
EVEN-ODD NUCLEI
HALF-LIFE
HALIDES
HALOGEN COMPOUNDS
HEAVY NUCLEI
HOURS LIVING RADIOISOTOPES
INJECTION
INTAKE
INTRAVENOUS INJECTION
IRIDIUM 191
IRIDIUM ISOTOPES
ISOMERIC TRANSITION ISOTOPES
ISOTOPES
MAMMALS
MAN
MEDICINE
MINUTES LIVING RADIOISOTOPES
NATIONAL ORGANIZATIONS
NONMETALS
NUCLEAR MEDICINE
NUCLEI
ODD-EVEN NUCLEI
OSMIUM 191
OSMIUM CHLORIDES
OSMIUM COMPOUNDS
OSMIUM ISOTOPES
PERFORMANCE
PH VALUE
POTASSIUM CHLORIDES
POTASSIUM COMPOUNDS
PRIMATES
RADIATION EFFECTS
RADIOACTIVITY
RADIOISOTOPE GENERATORS
RADIOISOTOPES
RADIOLOGY
REFRACTORY METAL COMPOUNDS
RESEARCH PROGRAMS
SECONDS LIVING RADIOISOTOPES
SODIUM CHLORIDES
SODIUM COMPOUNDS
STABLE ISOTOPES
SYNTHESIS
TRANSITION ELEMENT COMPOUNDS
US DOE
US ORGANIZATIONS
VERTEBRATES
VERY HIGH TEMPERATURE
YIELDS