A new osmium-191/iridium-191m generator system
Ir-191m (t/sub 1/2/ 4.96 sec) has very attractive properties for radionuclide angiography and is obtained from the long-lived (15 d) Os-191 parent. Because of the long parent half-life, generators could have an extended shelf-life (2-3 weeks) if the problems of low Ir-191m yields and rapidly increasing Os-191 breakthrough could be overcome. A new /sup 191/Os//sup 191m/Ir generator system has now been developed involving adsorption of K/sub 2/OsCl/sub 6/ (Os-IV) on heat-treated (800/sup 0/C) activated coconut carbon. This system gives consistently good Ir-191m yields of --35-40% for a 2 ml bolus and low Os-191 breakthrough of --1 x 10/sup -4/%/bolus over a 2-3 week period. In addition, this simple system does not require a scavenger column and no radiolysis has been detected after loading up to 1 Ci of Os-191. The generator is prepared from 140-230 mesh carbon and eluted with pH 2 - 0.9% NaCl containing 0.25% KI. The use of KI in the eluting solution is critical for generator performance. Yield and breakthrough do not change for up to 250 elutions of the prototype system. The generator eluent is neutralized to physiological pH and isotonicity with 0.13 M Tris buffer immediately prior to intravenous injection. No adverse effects have been observed in studies in normal adult volunteers. This new system has a long shelf-life and represents a simple, readily available source of Ir-191m for radionuclide angiography.
- Research Organization:
- Nuclear Medicine Group, Oak Ridge National Lab., Oak Ridge, TN
- OSTI ID:
- 6704281
- Report Number(s):
- CONF-850611-; TRN: 87-015214
- Journal Information:
- J. Nucl. Med.; (United States), Vol. 26:5; Conference: 32. annual meeting of the Society of Nuclear Medicine, Houston, TX, USA, 2 Jun 1985
- Country of Publication:
- United States
- Language:
- English
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A new /sup 191/Os//sup 191m/Ir generator system for medical use
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Related Subjects
37 INORGANIC
ORGANIC
PHYSICAL AND ANALYTICAL CHEMISTRY
IRIDIUM 191
INTRAVENOUS INJECTION
RADIOISOTOPE GENERATORS
DESIGN
ACTIVATED CARBON
BIOLOGICAL RADIATION EFFECTS
BIOMEDICAL RADIOGRAPHY
BUFFERS
CHEMICAL PREPARATION
CHEMICAL REACTION YIELD
COORDINATED RESEARCH PROGRAMS
DOSE-RESPONSE RELATIONSHIPS
HALF-LIFE
MAN
OSMIUM 191
OSMIUM CHLORIDES
PERFORMANCE
PH VALUE
POTASSIUM CHLORIDES
RADIOACTIVITY
SODIUM CHLORIDES
US DOE
VERY HIGH TEMPERATURE
ADSORBENTS
ALKALI METAL COMPOUNDS
ANIMALS
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BIOLOGICAL EFFECTS
CARBON
CHLORIDES
CHLORINE COMPOUNDS
DAYS LIVING RADIOISOTOPES
DIAGNOSTIC TECHNIQUES
ELEMENTS
EVEN-ODD NUCLEI
HALIDES
HALOGEN COMPOUNDS
HEAVY NUCLEI
HOURS LIVING RADIOISOTOPES
INJECTION
INTAKE
IRIDIUM ISOTOPES
ISOMERIC TRANSITION ISOTOPES
ISOTOPES
MAMMALS
MEDICINE
MINUTES LIVING RADIOISOTOPES
NATIONAL ORGANIZATIONS
NONMETALS
NUCLEAR MEDICINE
NUCLEI
ODD-EVEN NUCLEI
OSMIUM COMPOUNDS
OSMIUM ISOTOPES
POTASSIUM COMPOUNDS
PRIMATES
RADIATION EFFECTS
RADIOISOTOPES
RADIOLOGY
REFRACTORY METAL COMPOUNDS
RESEARCH PROGRAMS
SECONDS LIVING RADIOISOTOPES
SODIUM COMPOUNDS
STABLE ISOTOPES
SYNTHESIS
TRANSITION ELEMENT COMPOUNDS
US ORGANIZATIONS
VERTEBRATES
YIELDS
550602* - Medicine- External Radiation in Diagnostics- (1980-)
400202 - Isotope Effects
Isotope Exchange
& Isotope Separation