Osmium-191/iridium-191m generator based on silica gel impregnated with tridodecylmethylammonium chloride

Journal Article · Sat Apr 01 04:00:00 EST 1989 · J. Nucl. Med.; (United States)

OSTI ID:5825688

Issachar, D; Abrashkin, S; Weininger, J; Zemach, D; Lubin, E; Hellman, C; Trumper, J

A new separation system for an /sup 191/Os//sup 191m/Ir generator is described. The system is composed of two columns in a series: a main column, packed with silica gel impregnated with tridodecylmethylammonium chloride (loaded with high activity /sup 191/Os as an osmyl chloride); and a scavenger column, packed with activated charcoal. Iridium-191m is eluted from the generator by pH 1 saline. For clinical use the eluate is buffered by succinate solution before injection. This new system is characterized by high performance (approximately 25% 191mIr recovery with 5 X 10(-4)% /sup 191/Os breakthrough) and long shelf-life (3 wk). The buffered eluate is sterile, pyrogen-free, and nontoxic, and contains no /sup 192/Ir. It is suitable for first-pass radionuclide angiocardiography with a very low radiation dose to the patient.

• Research Organization: Soreq Nuclear Research Center, Yavne (Israel)
• OSTI ID: 5825688
• Journal Information: J. Nucl. Med.; (United States), Journal Name: J. Nucl. Med.; (United States) Vol. 30:4; ISSN JNMEA
• Country of Publication: United States
• Language: English

Related Subjects

38 RADIATION CHEMISTRY, RADIOCHEMISTRY, AND NUCLEAR CHEMISTRY
400703* -- Radiochemistry & Nuclear Chemistry-- Radioisotope Production
550601 -- Medicine-- Unsealed Radionuclides in Diagnostics
62 RADIOLOGY AND NUCLEAR MEDICINE
AMMONIUM COMPOUNDS
ANIMALS
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
DAYS LIVING RADIOISOTOPES
DESIGN
DOSES
DRUGS
EVEN-ODD NUCLEI
HEAVY NUCLEI
HOURS LIVING RADIOISOTOPES
IRIDIUM 191
IRIDIUM ISOTOPES
ISOMERIC NUCLEI
ISOMERIC TRANSITION ISOTOPES
ISOTOPE PRODUCTION
ISOTOPES
LABELLED COMPOUNDS
MAMMALS
MAN
MICE
MINUTES LIVING RADIOISOTOPES
NUCLEI
ODD-EVEN NUCLEI
OSMIUM 191
OSMIUM ISOTOPES
PRIMATES
RADIATION DOSES
RADIOISOTOPE GENERATORS
RADIOISOTOPES
RADIOPHARMACEUTICALS
RODENTS
SECONDS LIVING RADIOISOTOPES
STABLE ISOTOPES
VERTEBRATES