Development of a new osmium-191: Iridium-191m radionuclide generator: Final report

Technical Report · Wed Dec 31 04:00:00 EST 1986

OSTI ID:6708730

Treves, S; Packard, A B

The use of iridium-191m (T/sub 1/2/ = 5s) for first-pass radionuclide angiography offers the potential advantages of lower patient radiation dose and the ability to obtain repeated studies without interference from the previously administered radioisotope. These potential advantages have been offset by the absence of satisfactory /sup 191/Os-/sup 191m/Ir generators. The goal of this project was, therefore, the development of an /sup 191/Os-/sup 191m/Ir generator that would be suitable for clinical use. This goal was first sought through modifications of an existing /sup 191/Os-/sup 191m/Ir generator design (i.e., changes in the ion exchange material and eluent) but these changes did not lead to the required improvements. A new approach was then undertaken in which different chemical forms of the /sup 191/Os parent were evaluated in prototype generators. The complex trans-dioxobisoxalatoosmate (VI) led to a generator with higher /sup 191m/Ir yield (25 to 30%/mL) and lower /sup 191/Os breakthrough (<5 x 10/sup -4/%) with a more physiologically compatible eluent than had been previously achieved. Toxicity studies were conducted on the eluate and an IND subsequently obtained. While this is not a final solution to the problem of developing a clinically acceptable /sup 191/Os-/sup 191m/Ir generator, the ''oxalate'' generator is the most significant improvement of the /sup 191/Os-/sup 191m/Ir generator to date and will be used in an expanded program of clinical studies. 16 refs., 16 tabs.

• Research Organization: Children's Hospital Corp., Boston, MA (USA)
• DOE Contract Number: AC02-82ER60084
• OSTI ID: 6708730
• Report Number(s): DOE/ER/60084-6; ON: DE87007736
• Country of Publication: United States
• Language: English

Related Subjects

38 RADIATION CHEMISTRY, RADIOCHEMISTRY, AND NUCLEAR CHEMISTRY
400703 -- Radiochemistry &amp; Nuclear Chemistry-- Radioisotope Production
550601* -- Medicine-- Unsealed Radionuclides in Diagnostics
62 RADIOLOGY AND NUCLEAR MEDICINE
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
CARBOXYLIC ACID SALTS
CHROMATOGRAPHY
DAYS LIVING RADIOISOTOPES
DESIGN
EVEN-ODD NUCLEI
HEAVY NUCLEI
HOURS LIVING RADIOISOTOPES
ION EXCHANGE CHROMATOGRAPHY
IRIDIUM 191
IRIDIUM ISOTOPES
ISOMERIC TRANSITION ISOTOPES
ISOTOPES
MINUTES LIVING RADIOISOTOPES
NUCLEI
ODD-EVEN NUCLEI
OSMIUM 191
OSMIUM ISOTOPES
OXALATES
RADIOISOTOPE GENERATORS
RADIOISOTOPES
SECONDS LIVING RADIOISOTOPES
SEPARATION PROCESSES
STABLE ISOTOPES