Development of the osmium-191. -->. iridium-191m radionuclide generator. Annual report

Technical Report · Tue Apr 30 04:00:00 EDT 1985

OSTI ID:5564870

Treves, S; Packard, A B

The use of /sup 191m/Ir in radionuclide angiography has been the subject of increasing interest in recent years. The /sup 191/Os-/sup 191m/Ir generator that has been used for these studies suffers, however, from low /sup 191m/Ir yield (10%/ml) and higher than desirable /sup 191/Os breakthrough (5 x 10/sup -3/%). We have recently developed a /sup 191m/Ir generator that has higher yield (25 to 30%/ml) and lower breakthrough (<5 x 10/sup -4/%) when eluted with an eluent (0.001 M oxalic acid/0.9% saline) that does not require buffering prior to injection. Studies within the last year have shown the eluate of this generator to be non-toxic at up to 100 times the expected human dose and work is in progress to obtain approval for human use of this system. While a significant improvement over past generator designs, the yield of this generator is still modest and the evaluation of new osmium complexes for use on the generator has continued. Clinical studies involving the use of /sup 191m/Ir for first-pass angiography in adults and children have continued. A comparison of ejection fractions measured in adults with both /sup 99m/Tc and /sup 191m/Ir has confirmed the feasibilty of /sup 191m/Ir for radionuclide angiography in both the left and right ventricles of adults. Studies in collaboration with Baylor Medical College have demonstrated the efficacy of /sup 191m/Ir in combination with the multi-wire gamma camera. 31 refs., 2 figs., 10 tabs.

• Research Organization: Children's Hospital Medical Center, Boston, MA (USA). Dept. of Radiology
• DOE Contract Number: AC02-82ER60084
• OSTI ID: 5564870
• Report Number(s): DOE/ER/60084-4; ON: DE85011185
• Country of Publication: United States
• Language: English

Related Subjects

38 RADIATION CHEMISTRY, RADIOCHEMISTRY, AND NUCLEAR CHEMISTRY
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560151 -- Radiation Effects on Animals-- Man
560152 -- Radiation Effects on Animals-- Animals
59 BASIC BIOLOGICAL SCIENCES
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMALS
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BIOMEDICAL RADIOGRAPHY
BLOOD VESSELS
BODY
CARBOXYLIC ACID SALTS
CARBOXYLIC ACIDS
CARDIOVASCULAR SYSTEM
DATA
DAYS LIVING RADIOISOTOPES
DESIGN
DIAGNOSTIC TECHNIQUES
DICARBOXYLIC ACIDS
DISSOLUTION
DOGS
DOSES
ENERGY-LEVEL TRANSITIONS
EVEN-ODD NUCLEI
EXPERIMENTAL DATA
FEASIBILITY STUDIES
HEART
HEAVY NUCLEI
HOURS LIVING RADIOISOTOPES
HUMAN POPULATIONS
INFORMATION
ION EXCHANGE
IRIDIUM 191
IRIDIUM ISOTOPES
ISOMERIC TRANSITION ISOTOPES
ISOMERIC TRANSITIONS
ISOTOPE PRODUCTION
ISOTOPES
LEACHING
MAMMALS
MEDICINE
MINUTES LIVING RADIOISOTOPES
NUCLEAR MEDICINE
NUCLEI
NUMERICAL DATA
ODD-EVEN NUCLEI
ORGANIC ACIDS
ORGANIC COMPOUNDS
ORGANIC POLYMERS
ORGANS
OSMIUM 191
OSMIUM ISOTOPES
OXALATES
OXALIC ACID
PETROCHEMICALS
PETROLEUM PRODUCTS
POLYMERS
POPULATIONS
RADIATION DOSES
RADIOISOTOPE GENERATORS
RADIOISOTOPES
RADIOLOGY
RESINS
SECONDS LIVING RADIOISOTOPES
SEPARATION PROCESSES
STABLE ISOTOPES
TOXICITY
VERTEBRATES