Development of the Osmium-191->Iridium-191m radionuclide generator. Annual report

Technical Report · Tue May 01 04:00:00 EDT 1984

OSTI ID:6834440

Treves, S; Packard, A

The use of the ultrashort-lived radionuclide IR-191m (T/sub 1/2/=5s) for radionuclide angiography results in a lower patient radiation dose, higher photon flux, and allows repeated studies that are not possible with the radionuclide currently employed for these studies (Tc-99m, T/sub 1/2/=6h). The Os-191->Ir-191m generator currently being used in clinical studies suffers, however, from low Ir-191m yield (10%), high Os-191 breakthrough (5 x 10/sup -3/%), and an eluent (at pH 1) that must be buffered prior to injection. Initial efforts to improve the performance of this generator met with only limited success. We have, therefore, concentrated on the development of a completely new generator system. In the last year these investigations have led to a new generator of improved Ir-191m yield (20 to 25%), dramatically lower Os-191 breakthrough (5 x 10/sup -4/%), and an eluent that does not require buffering prior to injection. In addition, this generator has been found to be stable for at least 10 days and does not require a scavenger column to achieve low breakthrough. Clinical studies have continued at Children's Hospital in pediatric patients and at Beth Israel Hospital in adult patients. 19 references, 1 figure, 10 tables.

• Research Organization: Harvard Medical School, Boston, MA (USA)
• DOE Contract Number: AC02-82ER60084
• OSTI ID: 6834440
• Report Number(s): DOE/ER/60084-3; ON: DE84012460
• Country of Publication: United States
• Language: English

Related Subjects

550601* -- Medicine-- Unsealed Radionuclides in Diagnostics
62 RADIOLOGY AND NUCLEAR MEDICINE
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BIOMEDICAL RADIOGRAPHY
BLOOD VESSELS
BODY
CARDIOVASCULAR SYSTEM
DATA
DAYS LIVING RADIOISOTOPES
DIAGNOSTIC TECHNIQUES
DOSES
EVEN-ODD NUCLEI
EXPERIMENTAL DATA
HEAVY NUCLEI
HOURS LIVING RADIOISOTOPES
INFORMATION
IRIDIUM 191
IRIDIUM ISOTOPES
ISOMERIC TRANSITION ISOTOPES
ISOTOPES
MEDICINE
MINUTES LIVING RADIOISOTOPES
NUCLEAR MEDICINE
NUCLEI
NUMERICAL DATA
ODD-EVEN NUCLEI
ORGANS
OSMIUM 191
OSMIUM ISOTOPES
PERFORMANCE
PH VALUE
RADIATION DOSES
RADIOISOTOPE GENERATORS
RADIOISOTOPES
RADIOLOGY
SECONDS LIVING RADIOISOTOPES
STABLE ISOTOPES