Dexamethasone: a potent blocker for radiation-induced taste aversion in rats
Journal Article
·
· Pharmacol., Biochem. Behav.; (United States)
Rats, trained to drink water during a single 30-min period each day, were then given 0.1% saccharin twice a week and water on other days for 30 min. If 20 rad of radiation (0.2 Gy) were given each time 30 to 40 min after the saccharin the rats developed a profound aversion to saccharin during the course of three weeks, whereas control groups failed to do so. This paradigm was then used to test the ability of drugs, given twice weekly immediately after the saccharin, to prevent the development during three weeks of an aversion when 20 rad was given, 30 to 40 min later. Insulin, domperidone, haloperidol, acetylsalicylic acid, naloxone, chlorpheniramine, cimetidine, and dimethyl sulphoxide were tested without notable success. However dexamethasone, at doses ranging from 0.013 mg/kg to 1.3 mg/kg, significantly attenuated the conditioned taste aversion by up to 60 percent. The results are discussed in terms of a search for an antinauseant and antiemetic drug effective against radiation in man.
- Research Organization:
- Defence Research Establishment Ottawa, Canada
- OSTI ID:
- 6793863
- Journal Information:
- Pharmacol., Biochem. Behav.; (United States), Journal Name: Pharmacol., Biochem. Behav.; (United States) Vol. 17:2; ISSN PBBHA
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
550100 -- Behavioral Biology
551000 -- Physiological Systems
560152* -- Radiation Effects on Animals-- Animals
59 BASIC BIOLOGICAL SCIENCES
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ADRENAL HORMONES
ANIMALS
AVOIDANCE
AZOLES
BEHAVIOR
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
BODY
CORTICOSTEROIDS
DEXAMETHASONE
DOSES
FLAVOR
GLUCOCORTICOIDS
HETEROCYCLIC COMPOUNDS
HORMONES
HYDROXY COMPOUNDS
KETONES
MAMMALS
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
ORGANIC OXYGEN COMPOUNDS
ORGANIC SULFUR COMPOUNDS
ORGANOLEPTIC PROPERTIES
ORGANS
PREGNANES
RADIATION DOSES
RADIATION EFFECTS
RADIOINDUCTION
RADIOSENSITIVITY EFFECTS
RATS
RODENTS
SACCHARIN
SENSE ORGANS
STEROID HORMONES
STEROIDS
TASTE BUDS
THIAZOLES
VERTEBRATES
551000 -- Physiological Systems
560152* -- Radiation Effects on Animals-- Animals
59 BASIC BIOLOGICAL SCIENCES
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ADRENAL HORMONES
ANIMALS
AVOIDANCE
AZOLES
BEHAVIOR
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
BODY
CORTICOSTEROIDS
DEXAMETHASONE
DOSES
FLAVOR
GLUCOCORTICOIDS
HETEROCYCLIC COMPOUNDS
HORMONES
HYDROXY COMPOUNDS
KETONES
MAMMALS
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
ORGANIC OXYGEN COMPOUNDS
ORGANIC SULFUR COMPOUNDS
ORGANOLEPTIC PROPERTIES
ORGANS
PREGNANES
RADIATION DOSES
RADIATION EFFECTS
RADIOINDUCTION
RADIOSENSITIVITY EFFECTS
RATS
RODENTS
SACCHARIN
SENSE ORGANS
STEROID HORMONES
STEROIDS
TASTE BUDS
THIAZOLES
VERTEBRATES