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Effects of antiemetics on the acquisition and recall of radiation- and lithium chloride-induced conditioned taste aversions

Journal Article · · Pharmacol., Biochem. Behav.; (United States)
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A series of experiments were run to evaluate the effect of antiemetics on the acquisition and recall of a conditioned taste aversion induced by exposure to ionizing radiation or by injection of lithium chloride. Groups of male rats were exposed to 100 rad gamma radiation or 3 mEq/kg lithium chloride following consumption of a 10% sucrose solution. They were then injected with saline or with one of three antiemetics (prochlorperazine, trimethobenzamide, or cyclizine) at dose levels that have been reported to be effective in attenuating a previously acquired lithium chloride-induced taste aversion. The pretreatments with antiemetics had no effect on the acquisition or recall of either the lithium chloride- or radiation-induced taste aversion. The data suggest that antiemetics do not disrupt lithium chloride-induced taste aversions as previously reported, nor do they effect radiation-induced taste aversion learning.
Research Organization:
Behavioral Sciences Department, Armed Forces Radiobiology Research Institute, Bethesda, MD
OSTI ID:
5505314
Journal Information:
Pharmacol., Biochem. Behav.; (United States), Journal Name: Pharmacol., Biochem. Behav.; (United States) Vol. 18:4; ISSN PBBHA
Country of Publication:
United States
Language:
English

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Related Subjects

550100* -- Behavioral Biology
560152 -- Radiation Effects on Animals-- Animals
59 BASIC BIOLOGICAL SCIENCES
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ALKALI METAL COMPOUNDS
ANIMALS
BEHAVIOR
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
BODY
CHLORIDES
CHLORINE COMPOUNDS
CONDITIONED REFLEXES
DRUGS
FLAVOR
HALIDES
HALOGEN COMPOUNDS
LEARNING
LITHIUM CHLORIDES
LITHIUM COMPOUNDS
LITHIUM HALIDES
MAMMALS
ORGANOLEPTIC PROPERTIES
ORGANS
RADIATION EFFECTS
RATS
REFLEXES
RODENTS
SENSE ORGANS
SYMPTOMS
TASTE BUDS
VERTEBRATES
VOMITING