Effects of phenobarbital on taste aversion induced by x-radiation

Journal Article · Sat Dec 01 04:00:00 EST 1979 · Pharmacol., Biochem. Behav.; (United States)

DOI:https://doi.org/10.1016/0091-3057(79)90267-3· OSTI ID:6279627

Jolicoeur, F B; Wayner, M J; Rondeau, D B; Merkel, A D; Bassano, D A

The effects of phenobarbital on taste aversion induced by x-radiation were examined. Rats were adapted to a 23 hr 50 min water deprivation schedule. On the Treatment Day animals were given a novel 0.125% Na saccharin solution during the 10 min drinking session and were then exposed to 100 rads of x-radiation. The saccharin solution was presented again on six subsequent Test Days. Phenobarbital in doses of 20, 40, 60 and 80 mg/kg was adminstered 15 min prior to drinking on the first Test Day. Results demonstrate the phenobarbital in all doses tested has a significant attenuating effect on radiation induced taste aversion.

• Research Organization: Syracuse Univ., NY
• OSTI ID: 6279627
• Journal Information: Pharmacol., Biochem. Behav.; (United States), Journal Name: Pharmacol., Biochem. Behav.; (United States) Vol. 11:6; ISSN PBBHA
• Country of Publication: United States
• Language: English

Related Subjects

560152* -- Radiation Effects on Animals-- Animals
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANESTHETICS
ANIMALS
ANTICONVULSANTS
AVOIDANCE
AZINES
AZOLES
BARBITURATES
BEHAVIOR
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
BODY
CENTRAL NERVOUS SYSTEM DEPRESSANTS
DRUGS
ELECTROMAGNETIC RADIATION
FLAVOR
HETEROCYCLIC COMPOUNDS
HYPNOTICS AND SEDATIVES
IONIZING RADIATIONS
MAMMALS
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
ORGANIC OXYGEN COMPOUNDS
ORGANIC SULFUR COMPOUNDS
ORGANOLEPTIC PROPERTIES
ORGANS
PHENOBARBITAL
PYRIMIDINES
RADIATION EFFECTS
RADIATIONS
RATS
RESPONSE MODIFYING FACTORS
RODENTS
SACCHARIN
SENSE ORGANS
SYNERGISM
TASTE BUDS
THIAZOLES
VERTEBRATES
X RADIATION