Drugs and taste aversion

Journal Article · · Neurosci. Biobehav. Rev.; (United States)

DOI:https://doi.org/10.1016/0149-7634(81)90010-5· OSTI ID:5402366

Rondeau, D B; Jolicoeur, F B; Merkel, A D; Wayner, M J

The literature on the effects of drugs on the acquisition and the magnitude of taste aversion is reviewed and discussed. Then, the results of a series of experiments on the effects of phenobarbital and related drugs on taste aversion are reported. A standard taste aversion model was used in all experiments; test drugs were injected prior to drinking in a one bottle situation on the first test day following the taste aversion treatment. Phenobarbital in doses ranging from 20 to 80 mg/kg significantly attenuated taste aversion induced by lithium chloride (LiCl) and x-radiation, the maximal effect occurred with the 60 mg/kg dose. The attenuating effect was found to be dependent upon the magnitude of the aversion to the sapid solution. Phenobarbital completely abolished aversion produced by 0.375 mEq LiCl while the attenuation effect decreased linearly with higher doses of LiCl. Results also indicate that phenobarbital's attenuating effect cannot be solely attributed to its dipsogenic characteristic or to its state dependent learning effect. Attenuation of LiCl aversion to a saccharin solution was also observed following single doses of amobarbital, 30 mg/kg, pentobarbital, 15 mg/kg, and chloropromazine, 0.75 mg/kg. Taste aversion was not affected by other doses of those drugs or by hexobarbital, barbital, and chlordiazepoxide. Phenobarbital's attenuating effect on taste aversion is discussed in relation to other known behavioral and neurophysiological effects of the drug.

• OSTI ID: 5402366
• Journal Information: Neurosci. Biobehav. Rev.; (United States), Journal Name: Neurosci. Biobehav. Rev.; (United States) Vol. 5:2; ISSN NBRED
• Country of Publication: United States
• Language: English

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59 BASIC BIOLOGICAL SCIENCES
62 RADIOLOGY AND NUCLEAR MEDICINE
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ALKALI METAL COMPOUNDS
ANESTHETICS
ANTICONVULSANTS
AVOIDANCE
AZINES
BARBITURATES
BEHAVIOR
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
BODY
CENTRAL NERVOUS SYSTEM AGENTS
CENTRAL NERVOUS SYSTEM DEPRESSANTS
CHLORIDES
CHLORINE COMPOUNDS
CONDITIONED REFLEXES
DOSE-RESPONSE RELATIONSHIPS
DRUGS
FLAVOR
HALIDES
HALOGEN COMPOUNDS
HETEROCYCLIC COMPOUNDS
HYPNOTICS AND SEDATIVES
LITHIUM CHLORIDES
LITHIUM COMPOUNDS
LITHIUM HALIDES
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
ORGANIC OXYGEN COMPOUNDS
ORGANOLEPTIC PROPERTIES
ORGANS
PHENOBARBITAL
PSYCHOTROPIC DRUGS
PYRIMIDINES
RADIATION EFFECTS
RADIATIONS
REFLEXES
SENSE ORGANS
SENSITIVITY
TASTE BUDS