Effects of 5 Thio-D-Glucose on cellular adenosine triphosphate levels and deoxyribonucleic acid rejoining in hypoxic and aerobic Chinese hamster cells. [X-rays]
Conference
·
· Radiology; (United States)
OSTI ID:6793006
Intracellular adenosine triphosphate (ATP) levels were measured in both hypoxic and aerobic cultures of V79 Chinese hamster cells treated with 5-thio-D-glucose (5-SH-D-Glc). This glucose analog, a known inhibitor of D-glucose transport and metabolism, reduced ATP in cell cultures allowed to become hypoxic by cell metabolism, but not in aerobic cultures treated similarly. Cells depleted of ATP were unable to rejoin x-ray induced deoxyribonucleic acid (DNA) strand breaks as measured by the alkaline sucrose gradient sedimentation technique. The inference for radiation therapy is that inhibition of glucose metabolism selectively depletes energy reserves in hypoxic cells, rendering these cells more radiosensitive and leading to a more effective tumor treatment.
- Research Organization:
- Univ. of Arkansas, Little Rock
- OSTI ID:
- 6793006
- Conference Information:
- Journal Name: Radiology; (United States) Journal Volume: 137:1
- Country of Publication:
- United States
- Language:
- English
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· Radiology; (United States)
·
OSTI ID:7309609
Related Subjects
550500 -- Metabolism
560121* -- Radiation Effects on Cells-- External Source-- (-1987)
59 BASIC BIOLOGICAL SCIENCES
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
AEROBIC CONDITIONS
ALDEHYDES
ANIMAL CELLS
ANIMALS
ANOXIA
ATP
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
BIOLOGICAL RECOVERY
BIOLOGICAL REPAIR
CARBOHYDRATES
CHEMICAL REACTIONS
CONNECTIVE TISSUE CELLS
DECOMPOSITION
DNA
EARLY RADIATION EFFECTS
ELECTROMAGNETIC RADIATION
FIBROBLASTS
GLUCOSE
GLYCOLYSIS
HAMSTERS
HEXOSES
INHIBITION
IONIZING RADIATIONS
MAMMALS
MONOSACCHARIDES
NUCLEIC ACIDS
NUCLEOTIDES
ORGANIC COMPOUNDS
OXYGEN ENHANCEMENT RATIO
RADIATION EFFECTS
RADIATIONS
RADIOINDUCTION
RECOVERY
REPAIR
RODENTS
SACCHARIDES
SOMATIC CELLS
STRAND BREAKS
VERTEBRATES
X RADIATION
560121* -- Radiation Effects on Cells-- External Source-- (-1987)
59 BASIC BIOLOGICAL SCIENCES
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
AEROBIC CONDITIONS
ALDEHYDES
ANIMAL CELLS
ANIMALS
ANOXIA
ATP
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
BIOLOGICAL RECOVERY
BIOLOGICAL REPAIR
CARBOHYDRATES
CHEMICAL REACTIONS
CONNECTIVE TISSUE CELLS
DECOMPOSITION
DNA
EARLY RADIATION EFFECTS
ELECTROMAGNETIC RADIATION
FIBROBLASTS
GLUCOSE
GLYCOLYSIS
HAMSTERS
HEXOSES
INHIBITION
IONIZING RADIATIONS
MAMMALS
MONOSACCHARIDES
NUCLEIC ACIDS
NUCLEOTIDES
ORGANIC COMPOUNDS
OXYGEN ENHANCEMENT RATIO
RADIATION EFFECTS
RADIATIONS
RADIOINDUCTION
RECOVERY
REPAIR
RODENTS
SACCHARIDES
SOMATIC CELLS
STRAND BREAKS
VERTEBRATES
X RADIATION