Cytotoxic and radiosensitizing effects of 5-thio-D-glucose on hypoxic cells. [X radiation]
Journal Article
·
· Radiology; (United States)
OSTI ID:7309609
The effect of 5-thio-D-glucose on the viability and radiosensitivity of P8 15-X2 mouse mastocytoma cells was studied in vitro. By itself, this compound is specifically cytotoxic toward hypoxic cells; moreover, it sensitizes hypoxic cells to irradiation while it protects aerobic cells from radiation damage. These features, together with its low toxicity, suggest that 5-thio-D-glucose may be useful adjuvant to radiotherapy.
- Research Organization:
- Univ. of Minnesota, Minneapolis
- OSTI ID:
- 7309609
- Journal Information:
- Radiology; (United States), Journal Name: Radiology; (United States) Vol. 123:1; ISSN RADLA
- Country of Publication:
- United States
- Language:
- English
Similar Records
Potentiation of cytotoxicity of 5-thio-D-glucose on hypoxic cells by hyperthermia
Elimination of hypoxic protection by 5-thio-D-glucose in multicell spheroids
Failure of 5-thio-D-glucose to alter cell survival in irradiated or unirradiated EMT6 tumors
Conference
·
Sun Jul 01 00:00:00 EDT 1979
· Int. J. Radiat. Oncol., Biol. Phys.; (United States)
·
OSTI ID:6786527
Elimination of hypoxic protection by 5-thio-D-glucose in multicell spheroids
Journal Article
·
Thu Nov 30 23:00:00 EST 1978
· Cancer Res.; (United States)
·
OSTI ID:7097388
Failure of 5-thio-D-glucose to alter cell survival in irradiated or unirradiated EMT6 tumors
Journal Article
·
Fri Nov 30 23:00:00 EST 1984
· Radiat. Res.; (United States)
·
OSTI ID:5968685
Related Subjects
560121* -- Radiation Effects on Cells-- External Source-- (-1987)
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ALDEHYDES
ANIMAL CELLS
ANIMALS
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
CARBOHYDRATES
CRYOGENIC FLUIDS
ELECTROMAGNETIC RADIATION
ELEMENTS
FLUIDS
GLUCOSE
HEXOSES
IONIZING RADIATIONS
MAMMALS
MICE
MONOSACCHARIDES
NONMETALS
ORGANIC COMPOUNDS
ORGANIC SULFUR COMPOUNDS
OXYGEN
RADIATION EFFECTS
RADIATIONS
RADIOSENSITIVITY EFFECTS
RODENTS
SACCHARIDES
THIOLS
TUMOR CELLS
VERTEBRATES
X RADIATION
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ALDEHYDES
ANIMAL CELLS
ANIMALS
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
CARBOHYDRATES
CRYOGENIC FLUIDS
ELECTROMAGNETIC RADIATION
ELEMENTS
FLUIDS
GLUCOSE
HEXOSES
IONIZING RADIATIONS
MAMMALS
MICE
MONOSACCHARIDES
NONMETALS
ORGANIC COMPOUNDS
ORGANIC SULFUR COMPOUNDS
OXYGEN
RADIATION EFFECTS
RADIATIONS
RADIOSENSITIVITY EFFECTS
RODENTS
SACCHARIDES
THIOLS
TUMOR CELLS
VERTEBRATES
X RADIATION